GPR12 Inhibits Apoptosis in Epithelial Ovarian Cancer via the Activation of ERK1/2 Signaling

GPR12 Inhibits Apoptosis in Epithelial Ovarian Cancer via the Activation of ERK1/2 Signaling

Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies in women worldwide. G protein–coupled receptor 12 (GPR12) is a member of G protein–coupled receptors (GPCRs) and plays an important role in the regulation of cell proliferation and survival. However, its role in EOC...

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Bibliographic Details
Main Authors: Lu Wang, Da Yang, Yao Zhang, Yisheng Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
GPR12
EOC (epithelial ovarian cancer)
ERK1/2 signaling
proliferation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.932689/full

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