Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

Voltage-gated potassium (KV) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. KV channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a...

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Bibliographic Details
Main Authors: Briana M Bohannon, Jessica J Jowais, Leif Nyberg, Vanessa Olivier-Meo, Valentina Corradi, D Peter Tieleman, Sara I Liin, H Peter Larsson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
polyunsaturated fatty acids
potassium channel
long QT syndrome
Online Access:https://elifesciences.org/articles/85773

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