Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults
Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-03-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00075/full |
| _version_ | 1818260486016204800 |
|---|---|
| author | Jacob Levman Jacob Levman Jacob Levman Patrick MacDonald Sean Rowley Natalie Stewart Ashley Lim Bryan Ewenson Albert Galaburda Emi Takahashi Emi Takahashi |
| author_facet | Jacob Levman Jacob Levman Jacob Levman Patrick MacDonald Sean Rowley Natalie Stewart Ashley Lim Bryan Ewenson Albert Galaburda Emi Takahashi Emi Takahashi |
| author_sort | Jacob Levman |
| collection | DOAJ |
| description | Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988 control subjects (aged 0–32 years), and extracted regionally distributed cortical thickness measurements, including average measurements as well as standard deviations which supports the assessment of intra-regional cortical thickness variability. The youngest autistic participants (<2.5 years) were diagnosed after imaging and were identified retrospectively. The largest effect sizes and the most common findings not previously published in the scientific literature involve abnormal intra-regional variability in cortical thickness affecting many (but not all) regions of the autistic brain, suggesting irregular gray matter development in autism that can be detected with MRI. Atypical developmental patterns have been detected as early as 0 years old in individuals who would later be diagnosed with autism. |
| first_indexed | 2024-12-12T18:32:06Z |
| format | Article |
| id | doaj.art-75522237f01745e1b0976d0739fe8972 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-12T18:32:06Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-75522237f01745e1b0976d0739fe89722022-12-22T00:15:53ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-03-011310.3389/fnhum.2019.00075313162Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to AdultsJacob Levman0Jacob Levman1Jacob Levman2Patrick MacDonald3Sean Rowley4Natalie Stewart5Ashley Lim6Bryan Ewenson7Albert Galaburda8Emi Takahashi9Emi Takahashi10Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical SchoolBoston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestown, MA, United StatesDepartment of Mathematics, Statistics and Computer Science, St. Francis Xavier UniversityAntigonish, NS, CanadaDivision of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Mathematics, Statistics and Computer Science, St. Francis Xavier UniversityAntigonish, NS, CanadaDivision of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical SchoolBoston, MA, United StatesDivision of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Mathematics, Statistics and Computer Science, St. Francis Xavier UniversityAntigonish, NS, CanadaDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolBoston, MA, United StatesDivision of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical SchoolBoston, MA, United StatesAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestown, MA, United StatesAutism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988 control subjects (aged 0–32 years), and extracted regionally distributed cortical thickness measurements, including average measurements as well as standard deviations which supports the assessment of intra-regional cortical thickness variability. The youngest autistic participants (<2.5 years) were diagnosed after imaging and were identified retrospectively. The largest effect sizes and the most common findings not previously published in the scientific literature involve abnormal intra-regional variability in cortical thickness affecting many (but not all) regions of the autistic brain, suggesting irregular gray matter development in autism that can be detected with MRI. Atypical developmental patterns have been detected as early as 0 years old in individuals who would later be diagnosed with autism.https://www.frontiersin.org/article/10.3389/fnhum.2019.00075/fullautisticcortical thicknessdevelopmentneuroanatomyvariability |
| spellingShingle | Jacob Levman Jacob Levman Jacob Levman Patrick MacDonald Sean Rowley Natalie Stewart Ashley Lim Bryan Ewenson Albert Galaburda Emi Takahashi Emi Takahashi Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults Frontiers in Human Neuroscience autistic cortical thickness development neuroanatomy variability |
| title | Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults |
| title_full | Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults |
| title_fullStr | Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults |
| title_full_unstemmed | Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults |
| title_short | Structural Magnetic Resonance Imaging Demonstrates Abnormal Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults |
| title_sort | structural magnetic resonance imaging demonstrates abnormal regionally differential cortical thickness variability in autism from newborns to adults |
| topic | autistic cortical thickness development neuroanatomy variability |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00075/full |
| work_keys_str_mv | AT jacoblevman structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT jacoblevman structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT jacoblevman structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT patrickmacdonald structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT seanrowley structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT nataliestewart structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT ashleylim structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT bryanewenson structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT albertgalaburda structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT emitakahashi structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults AT emitakahashi structuralmagneticresonanceimagingdemonstratesabnormalregionallydifferentialcorticalthicknessvariabilityinautismfromnewbornstoadults |