Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation During Human Terminal Erythropoiesis

Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation During Human Terminal Erythropoiesis

Translocator protein (TSPO) and voltage dependent anion channels (VDAC) are two proteins forming a macromolecular complex in the outer mitochondrial membrane that is involved in pleiotropic functions. Specifically, these proteins were described to regulate the clearance of damaged mitochondria by se...

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Bibliographic Details
Main Authors: Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Suella Martino, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
erythropoiesis
TSPO1
VDAC
mitophagy
PINK1
enucleation
Online Access:https://www.mdpi.com/1422-0067/21/23/9066

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