Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

Abstract Background The hair follicles (HFs) are barely regenerated after loss in injuries in mammals as well as in human beings. Recent studies have shown that the regenerative ability of HFs is age-related; however, the relationship between this phenomenon and the stem cell niche remains unclear....

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Bibliographic Details
Main Authors: Guang Yang, Haiyan Chen, Qun Chen, Jiayi Qiu, Mulan Qahar, Zhimeng Fan, Weiwei Chu, Edward E. Tredget, Yaojiong Wu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Inflammation and Regeneration
Subjects:
Hair follicles
Lgr5 stem cells
Interleukin-1alpha
Wound healing
Regeneration
HaCaT
Online Access:https://doi.org/10.1186/s41232-023-00265-7

Internet

https://doi.org/10.1186/s41232-023-00265-7

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