EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA
Aim. To study effects of sympathomimetic agents on electrocardiogram (ECG) indexes in patients with bronchial asthma (BA) in exacerbation stage complicated by respiratory insufficiency and sympathomimetic agents overdose.Material and methods. 40 patients with persistent BA of various severities with...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/379 |
| _version_ | 1797232458789289984 |
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| author | I. G. Fomina G. K. Makchnach D. A. Zateyschikova A. I. Tarzimanova |
| author_facet | I. G. Fomina G. K. Makchnach D. A. Zateyschikova A. I. Tarzimanova |
| author_sort | I. G. Fomina |
| collection | DOAJ |
| description | Aim. To study effects of sympathomimetic agents on electrocardiogram (ECG) indexes in patients with bronchial asthma (BA) in exacerbation stage complicated by respiratory insufficiency and sympathomimetic agents overdose.Material and methods. 40 patients with persistent BA of various severities with respiratory insufficiency and sympathomimetic agents overdose were investigated. ECG was performed and P wave, QRS, duration and dispersion of corrected QT interval (QTc) were analyzed.Results. Mean QTc dispersion correlated with asthma severity and was 76,8±5,9 ms1/2, 87,9±5,1 ms1/2, 87,8±3,1 ms1/2 in patients with mild, moderate and severe BA, respectively. Significant correlation between QTc dispersion and BA duration was found. QTc dispersion level was directly connected with duration of use of β-agonists and their overdose. Average QTc dispersion in patients who used more than 20 daily doses of inhaled β-agonists was 89,0±5,8 ms1/2.Conclusion. Increase in QTc dispersion directly depends on BA duration and severity. β-agonist overdose results in growth of QTc dispersion, which has arrhythmogenic potential. |
| first_indexed | 2024-03-08T14:06:01Z |
| format | Article |
| id | doaj.art-7559600258214603bc00dd18434ea85e |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T16:00:36Z |
| publishDate | 2015-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-7559600258214603bc00dd18434ea85e2024-04-01T07:43:24ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-12-0131152010.20996/1819-6446-2007-3-1-15-20379EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMAI. G. Fomina0G. K. Makchnach1D. A. Zateyschikova2A. I. Tarzimanova3Moscow Medical Academy named after I.M. SetchenovMoscow Medical Academy named after I.M. SetchenovMoscow Medical Academy named after I.M. SetchenovMoscow Medical Academy named after I.M. SetchenovAim. To study effects of sympathomimetic agents on electrocardiogram (ECG) indexes in patients with bronchial asthma (BA) in exacerbation stage complicated by respiratory insufficiency and sympathomimetic agents overdose.Material and methods. 40 patients with persistent BA of various severities with respiratory insufficiency and sympathomimetic agents overdose were investigated. ECG was performed and P wave, QRS, duration and dispersion of corrected QT interval (QTc) were analyzed.Results. Mean QTc dispersion correlated with asthma severity and was 76,8±5,9 ms1/2, 87,9±5,1 ms1/2, 87,8±3,1 ms1/2 in patients with mild, moderate and severe BA, respectively. Significant correlation between QTc dispersion and BA duration was found. QTc dispersion level was directly connected with duration of use of β-agonists and their overdose. Average QTc dispersion in patients who used more than 20 daily doses of inhaled β-agonists was 89,0±5,8 ms1/2.Conclusion. Increase in QTc dispersion directly depends on BA duration and severity. β-agonist overdose results in growth of QTc dispersion, which has arrhythmogenic potential.https://www.rpcardio.online/jour/article/view/379bronchial asthmasympathomimetic agent overdoserhythm disordersdispersion of qt interval |
| spellingShingle | I. G. Fomina G. K. Makchnach D. A. Zateyschikova A. I. Tarzimanova EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA Рациональная фармакотерапия в кардиологии bronchial asthma sympathomimetic agent overdose rhythm disorders dispersion of qt interval |
| title | EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_full | EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_fullStr | EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_full_unstemmed | EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_short | EFFECTS OF SYMPATHOMIMETIC AGENTS ON ELECTROCARDIOGRAM INDEXES IN PATIENTS WITH BRONCHIAL ASTHMA |
| title_sort | effects of sympathomimetic agents on electrocardiogram indexes in patients with bronchial asthma |
| topic | bronchial asthma sympathomimetic agent overdose rhythm disorders dispersion of qt interval |
| url | https://www.rpcardio.online/jour/article/view/379 |
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