Viral Suppression of RIPK1-Mediated Signaling
ABSTRACT Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2021-08-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.01723-21 |
| _version_ | 1818404294261473280 |
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| author | Darshika J. Udawatte Alan L. Rothman |
| author_facet | Darshika J. Udawatte Alan L. Rothman |
| author_sort | Darshika J. Udawatte |
| collection | DOAJ |
| description | ABSTRACT Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein kinase (MAPK) and interferon regulatory factor 3/7 (IRF3/7) phosphorylation, and cell death via apoptosis and necroptosis. Both cell death and inflammatory responses play a major role in controlling virus infections. Therefore, viruses have evolved multifaceted mechanisms to exploit host immune responses by targeting RIPK1. This review focuses on the current understanding of RIPK1-mediated inflammatory and cell death pathways and multiple mechanisms by which viruses manipulate these pathways by targeting RIPK1. We also discuss gaps in our knowledge regarding RIPK1-mediated signaling pathways and highlight potential avenues for future research. |
| first_indexed | 2024-12-14T08:37:52Z |
| format | Article |
| id | doaj.art-75599a8648d2457eb1dada87cc3b1529 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-14T08:37:52Z |
| publishDate | 2021-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-75599a8648d2457eb1dada87cc3b15292022-12-21T23:09:22ZengAmerican Society for MicrobiologymBio2150-75112021-08-0112410.1128/mBio.01723-21Viral Suppression of RIPK1-Mediated SignalingDarshika J. Udawatte0Alan L. Rothman1Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island, USAInstitute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island, USAABSTRACT Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein kinase (MAPK) and interferon regulatory factor 3/7 (IRF3/7) phosphorylation, and cell death via apoptosis and necroptosis. Both cell death and inflammatory responses play a major role in controlling virus infections. Therefore, viruses have evolved multifaceted mechanisms to exploit host immune responses by targeting RIPK1. This review focuses on the current understanding of RIPK1-mediated inflammatory and cell death pathways and multiple mechanisms by which viruses manipulate these pathways by targeting RIPK1. We also discuss gaps in our knowledge regarding RIPK1-mediated signaling pathways and highlight potential avenues for future research.https://journals.asm.org/doi/10.1128/mBio.01723-21apoptosisinflammationinnate immunitynecroptosisreceptor-interacting protein kinasesignal transduction |
| spellingShingle | Darshika J. Udawatte Alan L. Rothman Viral Suppression of RIPK1-Mediated Signaling mBio apoptosis inflammation innate immunity necroptosis receptor-interacting protein kinase signal transduction |
| title | Viral Suppression of RIPK1-Mediated Signaling |
| title_full | Viral Suppression of RIPK1-Mediated Signaling |
| title_fullStr | Viral Suppression of RIPK1-Mediated Signaling |
| title_full_unstemmed | Viral Suppression of RIPK1-Mediated Signaling |
| title_short | Viral Suppression of RIPK1-Mediated Signaling |
| title_sort | viral suppression of ripk1 mediated signaling |
| topic | apoptosis inflammation innate immunity necroptosis receptor-interacting protein kinase signal transduction |
| url | https://journals.asm.org/doi/10.1128/mBio.01723-21 |
| work_keys_str_mv | AT darshikajudawatte viralsuppressionofripk1mediatedsignaling AT alanlrothman viralsuppressionofripk1mediatedsignaling |