Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis
Abstract Background Vitamin D deficiency and frailty are common with aging. Previous studies examining vitamin D status and frailty have produced mixed results, and in particular, the shape of the association has not been well established. We examined the association between 25-hydroxyvitamin D (25O...
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | BMC Geriatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12877-018-0904-2 |
| _version_ | 1818291134441455616 |
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| author | Sang Yhun Ju June Young Lee Do Hoon Kim |
| author_facet | Sang Yhun Ju June Young Lee Do Hoon Kim |
| author_sort | Sang Yhun Ju |
| collection | DOAJ |
| description | Abstract Background Vitamin D deficiency and frailty are common with aging. Previous studies examining vitamin D status and frailty have produced mixed results, and in particular, the shape of the association has not been well established. We examined the association between 25-hydroxyvitamin D (25OHD) serum levels and frailty by performing a systematic review and dose-response meta-analysis. Methods We searched the PubMed, EMBASE and Cochrane Library databases of Elsevier through February 2017. Cross-sectional and cohort studies that reported adjusted risk ratios with 95% confidence intervals (CI) for frailty with ≥3 categories of 25OHD serum levels were selected. Data extraction was performed independently by two authors. The reported risk estimates for 25OHD categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data. Results The pooled risk estimate of frailty syndrome per 25 nmol/L increment in serum 25OHD concentration was 0.88 (95% CI = 0.82–0.95, I 2 = 86.8%) in the 6 cross-sectional studies and 0.89 (95% CI = 0.85–0.94, I 2 = 0.0%) in the 4 prospective cohort studies. Based on the Akaike information criteria (AIC), a linear model was selected (AIC for the nonlinear model: − 5.4, AIC for the linear model: − 6.8 in the prospective cohort studies; AIC for the linear model: − 13.6, AIC for the nonlinear model: − 1.77 in the cross-sectional studies). Conclusions This dose-response meta-analysis indicates that serum 25OHD levels are significantly and directly associated with the risk of frailty. Further studies should address the underlying mechanisms to explain this relationship and to determine whether vitamin D supplementation is effective for preventing frailty syndrome. |
| first_indexed | 2024-12-13T02:39:14Z |
| format | Article |
| id | doaj.art-755c94d2d1944fa88c9adaff87bc4747 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-13T02:39:14Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-755c94d2d1944fa88c9adaff87bc47472022-12-22T00:02:20ZengBMCBMC Geriatrics1471-23182018-09-0118111110.1186/s12877-018-0904-2Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysisSang Yhun Ju0June Young Lee1Do Hoon Kim2Department of Family Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Biostatistics, Korea University College of MedicineDepartment of Family Medicine, Korea University Ansan HospitalAbstract Background Vitamin D deficiency and frailty are common with aging. Previous studies examining vitamin D status and frailty have produced mixed results, and in particular, the shape of the association has not been well established. We examined the association between 25-hydroxyvitamin D (25OHD) serum levels and frailty by performing a systematic review and dose-response meta-analysis. Methods We searched the PubMed, EMBASE and Cochrane Library databases of Elsevier through February 2017. Cross-sectional and cohort studies that reported adjusted risk ratios with 95% confidence intervals (CI) for frailty with ≥3 categories of 25OHD serum levels were selected. Data extraction was performed independently by two authors. The reported risk estimates for 25OHD categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data. Results The pooled risk estimate of frailty syndrome per 25 nmol/L increment in serum 25OHD concentration was 0.88 (95% CI = 0.82–0.95, I 2 = 86.8%) in the 6 cross-sectional studies and 0.89 (95% CI = 0.85–0.94, I 2 = 0.0%) in the 4 prospective cohort studies. Based on the Akaike information criteria (AIC), a linear model was selected (AIC for the nonlinear model: − 5.4, AIC for the linear model: − 6.8 in the prospective cohort studies; AIC for the linear model: − 13.6, AIC for the nonlinear model: − 1.77 in the cross-sectional studies). Conclusions This dose-response meta-analysis indicates that serum 25OHD levels are significantly and directly associated with the risk of frailty. Further studies should address the underlying mechanisms to explain this relationship and to determine whether vitamin D supplementation is effective for preventing frailty syndrome.http://link.springer.com/article/10.1186/s12877-018-0904-2Vitamin D25-hydroxyvitamin DFrailtyElderlyCohort studiesCross-sectional studies |
| spellingShingle | Sang Yhun Ju June Young Lee Do Hoon Kim Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis BMC Geriatrics Vitamin D 25-hydroxyvitamin D Frailty Elderly Cohort studies Cross-sectional studies |
| title | Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis |
| title_full | Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis |
| title_fullStr | Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis |
| title_full_unstemmed | Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis |
| title_short | Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis |
| title_sort | low 25 hydroxyvitamin d levels and the risk of frailty syndrome a systematic review and dose response meta analysis |
| topic | Vitamin D 25-hydroxyvitamin D Frailty Elderly Cohort studies Cross-sectional studies |
| url | http://link.springer.com/article/10.1186/s12877-018-0904-2 |
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