The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR
We present computational fluid dynamics (CFD) results of virtual fractional flow reserve (vFFR) calculations, performed on reconstructed arterial geometries derived from a digital phantom (DP). The latter provides a convenient and parsimonious description of the main vessels of the left and right co...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Fluids |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-5521/7/6/201 |
| _version_ | 1797487583133958144 |
|---|---|
| author | Giulia Pederzani Krzysztof Czechowicz Nada Ghorab Paul D. Morris Julian P. Gunn Andrew J. Narracott David Rodney Hose Ian Halliday |
| author_facet | Giulia Pederzani Krzysztof Czechowicz Nada Ghorab Paul D. Morris Julian P. Gunn Andrew J. Narracott David Rodney Hose Ian Halliday |
| author_sort | Giulia Pederzani |
| collection | DOAJ |
| description | We present computational fluid dynamics (CFD) results of virtual fractional flow reserve (vFFR) calculations, performed on reconstructed arterial geometries derived from a digital phantom (DP). The latter provides a convenient and parsimonious description of the main vessels of the left and right coronary arterial trees, which, crucially, is CFD-compatible. Using our DP, we investigate the reconstruction error in what we deem to be the most relevant way—by evaluating the change in the computed value of vFFR, which results from varying (within representative clinical bounds) the selection of the virtual angiogram pair (defined by their viewing angles) used to segment the artery, the eccentricity and severity of the stenosis, and thereby, the CFD simulation’s luminal boundary. The DP is used to quantify reconstruction and computed haemodynamic error within the VIRTUheart<sup>TM</sup> software suite. However, our method and the associated digital phantom tool are readily transferable to equivalent, clinically oriented workflows. While we are able to conclude that error within the VIRTUheart<sup>TM</sup> workflow is suitably controlled, the principal outcomes of the work reported here are the demonstration and provision of a practical tool along with an exemplar methodology for evaluating error in a coronary segmentation process. |
| first_indexed | 2024-03-09T23:49:44Z |
| format | Article |
| id | doaj.art-755d43dacfeb4c42b1de769def0064c8 |
| institution | Directory Open Access Journal |
| issn | 2311-5521 |
| language | English |
| last_indexed | 2024-03-09T23:49:44Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj.art-755d43dacfeb4c42b1de769def0064c82023-11-23T16:37:01ZengMDPI AGFluids2311-55212022-06-017620110.3390/fluids7060201The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFRGiulia Pederzani0Krzysztof Czechowicz1Nada Ghorab2Paul D. Morris3Julian P. Gunn4Andrew J. Narracott5David Rodney Hose6Ian Halliday7Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield S10 2TN, UKWe present computational fluid dynamics (CFD) results of virtual fractional flow reserve (vFFR) calculations, performed on reconstructed arterial geometries derived from a digital phantom (DP). The latter provides a convenient and parsimonious description of the main vessels of the left and right coronary arterial trees, which, crucially, is CFD-compatible. Using our DP, we investigate the reconstruction error in what we deem to be the most relevant way—by evaluating the change in the computed value of vFFR, which results from varying (within representative clinical bounds) the selection of the virtual angiogram pair (defined by their viewing angles) used to segment the artery, the eccentricity and severity of the stenosis, and thereby, the CFD simulation’s luminal boundary. The DP is used to quantify reconstruction and computed haemodynamic error within the VIRTUheart<sup>TM</sup> software suite. However, our method and the associated digital phantom tool are readily transferable to equivalent, clinically oriented workflows. While we are able to conclude that error within the VIRTUheart<sup>TM</sup> workflow is suitably controlled, the principal outcomes of the work reported here are the demonstration and provision of a practical tool along with an exemplar methodology for evaluating error in a coronary segmentation process.https://www.mdpi.com/2311-5521/7/6/201digital phantomcoronary angiographyphysiologyfractional flow reservecomputational fluid dynamicspercutaneous coronary intervention |
| spellingShingle | Giulia Pederzani Krzysztof Czechowicz Nada Ghorab Paul D. Morris Julian P. Gunn Andrew J. Narracott David Rodney Hose Ian Halliday The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR Fluids digital phantom coronary angiography physiology fractional flow reserve computational fluid dynamics percutaneous coronary intervention |
| title | The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR |
| title_full | The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR |
| title_fullStr | The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR |
| title_full_unstemmed | The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR |
| title_short | The Use of Digital Coronary Phantoms for the Validation of Arterial Geometry Reconstruction and Computation of Virtual FFR |
| title_sort | use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual ffr |
| topic | digital phantom coronary angiography physiology fractional flow reserve computational fluid dynamics percutaneous coronary intervention |
| url | https://www.mdpi.com/2311-5521/7/6/201 |
| work_keys_str_mv | AT giuliapederzani theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT krzysztofczechowicz theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT nadaghorab theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT pauldmorris theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT julianpgunn theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT andrewjnarracott theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT davidrodneyhose theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT ianhalliday theuseofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT giuliapederzani useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT krzysztofczechowicz useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT nadaghorab useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT pauldmorris useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT julianpgunn useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT andrewjnarracott useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT davidrodneyhose useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr AT ianhalliday useofdigitalcoronaryphantomsforthevalidationofarterialgeometryreconstructionandcomputationofvirtualffr |