Are there three Subdivisions in the primate Subthalamic Nucleus?
The prevailing academic opinion holds that the subthalamic nucleus (STN) consists of three parts, each anatomically distinct and selectively associated with cognitive, emotional, or motor functioning. We independently tested this assumption by summarizing the results from 33 studies on STN subdivisi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2012.00014/full |
| _version_ | 1811299793660542976 |
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| author | Max C Keuken Max C Keuken Harry B.M. Uylings Stefan eGeyer Andreas eSchäfer Robert eTurner Birte U Forstmann Birte U Forstmann |
| author_facet | Max C Keuken Max C Keuken Harry B.M. Uylings Stefan eGeyer Andreas eSchäfer Robert eTurner Birte U Forstmann Birte U Forstmann |
| author_sort | Max C Keuken |
| collection | DOAJ |
| description | The prevailing academic opinion holds that the subthalamic nucleus (STN) consists of three parts, each anatomically distinct and selectively associated with cognitive, emotional, or motor functioning. We independently tested this assumption by summarizing the results from 33 studies on STN subdivisions in human and nonhuman primates. The studies were conducted from 1925 to 2010 and feature three different techniques: electrical lesions, anterograde and retrograde tracers, and classical cytoarchitectonics. Our results reveal scant evidence in support of a tripartite STN. Instead, our results show that the variability across studies is surprisingly large, both in the number of subdivisions and in their anatomical localization. We conclude that the number of subdivisions in the STN remains uncertain, and that academic consensus in support of a tripartite STN is presently unwarranted. |
| first_indexed | 2024-04-13T06:42:11Z |
| format | Article |
| id | doaj.art-755f2bda364d464a9d0e2bb17ea83d08 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-04-13T06:42:11Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-755f2bda364d464a9d0e2bb17ea83d082022-12-22T02:57:42ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292012-05-01610.3389/fnana.2012.0001424322Are there three Subdivisions in the primate Subthalamic Nucleus?Max C Keuken0Max C Keuken1Harry B.M. Uylings2Stefan eGeyer3Andreas eSchäfer4Robert eTurner5Birte U Forstmann6Birte U Forstmann7University of AmsterdamMax Planck Insititute for Human Cognitive and Brain SciencesVU University Medical CenterMax Planck Insititute for Human Cognitive and Brain SciencesMax Planck Insititute for Human Cognitive and Brain SciencesMax Planck Insititute for Human Cognitive and Brain SciencesUniversity of AmsterdamMax Planck Insititute for Human Cognitive and Brain SciencesThe prevailing academic opinion holds that the subthalamic nucleus (STN) consists of three parts, each anatomically distinct and selectively associated with cognitive, emotional, or motor functioning. We independently tested this assumption by summarizing the results from 33 studies on STN subdivisions in human and nonhuman primates. The studies were conducted from 1925 to 2010 and feature three different techniques: electrical lesions, anterograde and retrograde tracers, and classical cytoarchitectonics. Our results reveal scant evidence in support of a tripartite STN. Instead, our results show that the variability across studies is surprisingly large, both in the number of subdivisions and in their anatomical localization. We conclude that the number of subdivisions in the STN remains uncertain, and that academic consensus in support of a tripartite STN is presently unwarranted.http://journal.frontiersin.org/Journal/10.3389/fnana.2012.00014/fullSubthalamic NucleusSubdivisionsPrimate |
| spellingShingle | Max C Keuken Max C Keuken Harry B.M. Uylings Stefan eGeyer Andreas eSchäfer Robert eTurner Birte U Forstmann Birte U Forstmann Are there three Subdivisions in the primate Subthalamic Nucleus? Frontiers in Neuroanatomy Subthalamic Nucleus Subdivisions Primate |
| title | Are there three Subdivisions in the primate Subthalamic Nucleus? |
| title_full | Are there three Subdivisions in the primate Subthalamic Nucleus? |
| title_fullStr | Are there three Subdivisions in the primate Subthalamic Nucleus? |
| title_full_unstemmed | Are there three Subdivisions in the primate Subthalamic Nucleus? |
| title_short | Are there three Subdivisions in the primate Subthalamic Nucleus? |
| title_sort | are there three subdivisions in the primate subthalamic nucleus |
| topic | Subthalamic Nucleus Subdivisions Primate |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2012.00014/full |
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