On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me]
Earlier computational and bioinformatics analysis of several large protein datasets across 28 species showed that proteins involved in regulation and execution of programmed cell death (PCD) possess substantial amounts of intrinsic disorder. Based on the comprehensive analysis of these datasets by a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2013-09-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/2-190/v1 |
| _version_ | 1819055863985340416 |
|---|---|
| author | Alexey V Uversky Bin Xue Zhenling Peng Lukasz Kurgan Vladimir N Uversky |
| author_facet | Alexey V Uversky Bin Xue Zhenling Peng Lukasz Kurgan Vladimir N Uversky |
| author_sort | Alexey V Uversky |
| collection | DOAJ |
| description | Earlier computational and bioinformatics analysis of several large protein datasets across 28 species showed that proteins involved in regulation and execution of programmed cell death (PCD) possess substantial amounts of intrinsic disorder. Based on the comprehensive analysis of these datasets by a wide array of modern bioinformatics tools it was concluded that disordered regions of PCD-related proteins are involved in a multitude of biological functions and interactions with various partners, possess numerous posttranslational modification sites, and have specific evolutionary patterns (Peng et al. 2013). This study extends our previous work by providing information on the intrinsic disorder status of some of the major players of the three major PCD pathways: apoptosis, autophagy, and necroptosis. We also present a detailed description of the disorder status and interactomes of selected proteins that are involved in the p53-mediated apoptotic signaling pathways. |
| first_indexed | 2024-12-21T13:14:17Z |
| format | Article |
| id | doaj.art-7561bf33f83d461fa80efb0ca59047d6 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T13:14:17Z |
| publishDate | 2013-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-7561bf33f83d461fa80efb0ca59047d62022-12-21T19:02:47ZengF1000 Research LtdF1000Research2046-14022013-09-01210.12688/f1000research.2-190.v12102On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me]Alexey V Uversky0Bin Xue1Zhenling Peng2Lukasz Kurgan3Vladimir N Uversky4Center for Data Analytics and Biomedical Informatics, Department of Computer and Information Sciences, College of Science and Technology, Temple University, Philadelphia, PA, 19122, USADepartment of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, 33612, USADepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, CanadaDepartment of Electrical and Computer Engineering, University of Alberta, Edmonton, CanadaInstitute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Russian FederationEarlier computational and bioinformatics analysis of several large protein datasets across 28 species showed that proteins involved in regulation and execution of programmed cell death (PCD) possess substantial amounts of intrinsic disorder. Based on the comprehensive analysis of these datasets by a wide array of modern bioinformatics tools it was concluded that disordered regions of PCD-related proteins are involved in a multitude of biological functions and interactions with various partners, possess numerous posttranslational modification sites, and have specific evolutionary patterns (Peng et al. 2013). This study extends our previous work by providing information on the intrinsic disorder status of some of the major players of the three major PCD pathways: apoptosis, autophagy, and necroptosis. We also present a detailed description of the disorder status and interactomes of selected proteins that are involved in the p53-mediated apoptotic signaling pathways.http://f1000research.com/articles/2-190/v1Cellular Death & Stress ResponsesProtein Chemistry & Proteomics |
| spellingShingle | Alexey V Uversky Bin Xue Zhenling Peng Lukasz Kurgan Vladimir N Uversky On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me] F1000Research Cellular Death & Stress Responses Protein Chemistry & Proteomics |
| title | On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me] |
| title_full | On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me] |
| title_fullStr | On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me] |
| title_full_unstemmed | On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me] |
| title_short | On the intrinsic disorder status of the major players in programmed cell death pathways [v1; ref status: indexed, http://f1000r.es/1me] |
| title_sort | on the intrinsic disorder status of the major players in programmed cell death pathways v1 ref status indexed http f1000r es 1me |
| topic | Cellular Death & Stress Responses Protein Chemistry & Proteomics |
| url | http://f1000research.com/articles/2-190/v1 |
| work_keys_str_mv | AT alexeyvuversky ontheintrinsicdisorderstatusofthemajorplayersinprogrammedcelldeathpathwaysv1refstatusindexedhttpf1000res1me AT binxue ontheintrinsicdisorderstatusofthemajorplayersinprogrammedcelldeathpathwaysv1refstatusindexedhttpf1000res1me AT zhenlingpeng ontheintrinsicdisorderstatusofthemajorplayersinprogrammedcelldeathpathwaysv1refstatusindexedhttpf1000res1me AT lukaszkurgan ontheintrinsicdisorderstatusofthemajorplayersinprogrammedcelldeathpathwaysv1refstatusindexedhttpf1000res1me AT vladimirnuversky ontheintrinsicdisorderstatusofthemajorplayersinprogrammedcelldeathpathwaysv1refstatusindexedhttpf1000res1me |