Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET
Objective(s): In order to evaluate the effect of post-reconstruction Gaussian filtering on image quality and myocardial blood flow (MBF) measurement by dynamic N-13 ammonia positron emission tomography (PET), we compared various reconstruction and filtering methods with image characteristics. Method...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2014-10-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | http://aojnmb.mums.ac.ir/pdf_2841_33590e5d58c51e36c455b9944bb249fa.html |
| _version_ | 1818330653578493952 |
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| author | Hyeon Sik Kim Sang-Geon Cho Ju Han Kim Seong Young Kwon Byeongil Lee Hee-Seung Bom |
| author_facet | Hyeon Sik Kim Sang-Geon Cho Ju Han Kim Seong Young Kwon Byeongil Lee Hee-Seung Bom |
| author_sort | Hyeon Sik Kim |
| collection | DOAJ |
| description | Objective(s): In order to evaluate the effect of post-reconstruction Gaussian filtering on image quality and myocardial blood flow (MBF) measurement by dynamic N-13 ammonia positron emission tomography (PET), we compared various reconstruction and filtering methods with image characteristics. Methods: Dynamic PET images of three patients with coronary artery disease (male-female ratio of 2:1; age: 57, 53, and 76 years) were reconstructed, using filtered back projection (FBP) and ordered subset expectation maximization (OSEM) methods. OSEM reconstruction consisted of OSEM_2I, OSEM_4I, and OSEM_6I with 2, 4, and 6 iterations, respectively. The images, reconstructed and filtered by Gaussian filters of 5, 10, and 15 mm, were obtained, as well as non-filtered images. Visual analysis of image quality (IQ) was performed using a 3-grade scoring system by 2 independent readers, blinded to the reconstruction and filtering methods of stress images. Then, signal-to-noise ratio (SNR) was calculated by noise and contrast recovery (CR). Stress and rest MBF and coronary flow reserve (CFR) were obtained for each method. IQ scores, stress and rest MBF, and CFR were compared between the methods, using Chi-square and Kruskal-Wallis tests. Results: In the visual analysis, IQ was significantly higher by 10 mm Gaussian filtering, compared to other sizes of filter (PP=0.923 and 0.855 for readers 1 and 2, respectively). SNR was significantly higher in 10 mm Gaussian filter. There was a significant difference in stress and rest MBF between several vascular territories. However CFR was not significantly different according to various filtering methods. Conclusion: Post-reconstruction Gaussian filtering with a filter size of 10 mm significantly enhances the IQ of N-13 ammonia PET-CT, without changing the results of CFR calculation. . |
| first_indexed | 2024-12-13T13:07:23Z |
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| id | doaj.art-7561f633d0df458891ef7e13d9a7c0e1 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-13T13:07:23Z |
| publishDate | 2014-10-01 |
| publisher | Mashhad University of Medical Sciences |
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| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-7561f633d0df458891ef7e13d9a7c0e12022-12-21T23:44:46ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262014-10-01221041102841Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PETHyeon Sik Kim0Sang-Geon Cho1Ju Han Kim2Seong Young Kwon3Byeongil Lee4Hee-Seung Bom5Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-Gun, Jeollanamdo, South KoreaDepartment of Nuclear Medicine, Chonnam National University Hospital, Hwasun-Gun, Jeollanamdo, South KoreaDepartment of Cardiology, Chonnam National University Hospital, Hwasun-Gun, Jeollanamdo, South KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-Gun, Jeollanamdo, South KoreaKorea Photonics Technology Institute, Gwangju City, South KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-Gun, Jeollanamdo, South KoreaObjective(s): In order to evaluate the effect of post-reconstruction Gaussian filtering on image quality and myocardial blood flow (MBF) measurement by dynamic N-13 ammonia positron emission tomography (PET), we compared various reconstruction and filtering methods with image characteristics. Methods: Dynamic PET images of three patients with coronary artery disease (male-female ratio of 2:1; age: 57, 53, and 76 years) were reconstructed, using filtered back projection (FBP) and ordered subset expectation maximization (OSEM) methods. OSEM reconstruction consisted of OSEM_2I, OSEM_4I, and OSEM_6I with 2, 4, and 6 iterations, respectively. The images, reconstructed and filtered by Gaussian filters of 5, 10, and 15 mm, were obtained, as well as non-filtered images. Visual analysis of image quality (IQ) was performed using a 3-grade scoring system by 2 independent readers, blinded to the reconstruction and filtering methods of stress images. Then, signal-to-noise ratio (SNR) was calculated by noise and contrast recovery (CR). Stress and rest MBF and coronary flow reserve (CFR) were obtained for each method. IQ scores, stress and rest MBF, and CFR were compared between the methods, using Chi-square and Kruskal-Wallis tests. Results: In the visual analysis, IQ was significantly higher by 10 mm Gaussian filtering, compared to other sizes of filter (PP=0.923 and 0.855 for readers 1 and 2, respectively). SNR was significantly higher in 10 mm Gaussian filter. There was a significant difference in stress and rest MBF between several vascular territories. However CFR was not significantly different according to various filtering methods. Conclusion: Post-reconstruction Gaussian filtering with a filter size of 10 mm significantly enhances the IQ of N-13 ammonia PET-CT, without changing the results of CFR calculation. .http://aojnmb.mums.ac.ir/pdf_2841_33590e5d58c51e36c455b9944bb249fa.htmlGaussian filtering Myocardial blood flow PET image reconstruction |
| spellingShingle | Hyeon Sik Kim Sang-Geon Cho Ju Han Kim Seong Young Kwon Byeongil Lee Hee-Seung Bom Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET Asia Oceania Journal of Nuclear Medicine and Biology Gaussian filtering Myocardial blood flow PET image reconstruction |
| title | Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET |
| title_full | Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET |
| title_fullStr | Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET |
| title_full_unstemmed | Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET |
| title_short | Effect of Post-Reconstruction Gaussian Filtering on Image Quality and Myocardial Blood Flow Measurement with N-13 Ammonia PET |
| title_sort | effect of post reconstruction gaussian filtering on image quality and myocardial blood flow measurement with n 13 ammonia pet |
| topic | Gaussian filtering Myocardial blood flow PET image reconstruction |
| url | http://aojnmb.mums.ac.ir/pdf_2841_33590e5d58c51e36c455b9944bb249fa.html |
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