Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea
Abstract Background Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods Plasma levels of sRAGE were measur...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-022-02092-9 |
| _version_ | 1811230001655185408 |
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| author | Marta Marin-Oto David Sanz-Rubio Fernando Santamaría-Martos Ivan Benitez Ana L. Simon Marta Forner Pablo Cubero Ana Gil Manuel Sanchez-de-laTorre Ferran Barbe José M. Marin |
| author_facet | Marta Marin-Oto David Sanz-Rubio Fernando Santamaría-Martos Ivan Benitez Ana L. Simon Marta Forner Pablo Cubero Ana Gil Manuel Sanchez-de-laTorre Ferran Barbe José M. Marin |
| author_sort | Marta Marin-Oto |
| collection | DOAJ |
| description | Abstract Background Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods Plasma levels of sRAGE were measured in 317 subjects at baseline (57 heathy nonsmokers [HNS], 84 healthy smokers [HS], 79 OSA, 62 COPD and 35 OSA-COPD overlap patients) and in 294 subjects after one year of follow-up (50 HNS, 74 HS, 77 OSA, 60 COPD and 33 overlap). Results After adjusting for age, sex, smoking status and body mass index, sRAGE levels showed a reduction in OSA (− 12.5%, p = 0.005), COPD (− 14.8%, p < 0.001) and OSA-COPD overlap (− 12.3%, p = 0.02) compared with HNS. There were no differences when comparing sRAGE plasma levels between overlap patients and those with OSA or COPD alone. At follow-up, sRAGE levels did not change significantly in healthy subjects, COPD and OSA or OSA-COPD overlap nontreated with continuous positive airway pressure (CPAP). Moreover, in patients with OSA and OSA-COPD overlap who were treated with CPAP, sRAGE increased significantly. Conclusions The levels of sRAGE are reduced in COPD and OSA. Treatment with CPAP appears to improve sRAGE levels in patients with OSA who also had COPD. |
| first_indexed | 2024-04-12T10:21:30Z |
| format | Article |
| id | doaj.art-75623eb657224e029f5dfaa59e0ef835 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-12T10:21:30Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-75623eb657224e029f5dfaa59e0ef8352022-12-22T03:37:04ZengBMCRespiratory Research1465-993X2022-06-012311910.1186/s12931-022-02092-9Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoeaMarta Marin-Oto0David Sanz-Rubio1Fernando Santamaría-Martos2Ivan Benitez3Ana L. Simon4Marta Forner5Pablo Cubero6Ana Gil7Manuel Sanchez-de-laTorre8Ferran Barbe9José M. Marin10Translational Research Unit, Aragón Health Research InstituteTranslational Research Unit, Aragón Health Research InstituteRespiratory Department, Hospital Arnau de Vilanova, IRB-LleidaRespiratory Department, Hospital Arnau de Vilanova, IRB-LleidaTranslational Research Unit, Aragón Health Research InstituteTranslational Research Unit, Aragón Health Research InstituteTranslational Research Unit, Aragón Health Research InstituteTranslational Research Unit, Aragón Health Research InstituteRespiratory Department, Hospital Arnau de Vilanova, IRB-LleidaRespiratory Department, Hospital Arnau de Vilanova, IRB-LleidaTranslational Research Unit, Aragón Health Research InstituteAbstract Background Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods Plasma levels of sRAGE were measured in 317 subjects at baseline (57 heathy nonsmokers [HNS], 84 healthy smokers [HS], 79 OSA, 62 COPD and 35 OSA-COPD overlap patients) and in 294 subjects after one year of follow-up (50 HNS, 74 HS, 77 OSA, 60 COPD and 33 overlap). Results After adjusting for age, sex, smoking status and body mass index, sRAGE levels showed a reduction in OSA (− 12.5%, p = 0.005), COPD (− 14.8%, p < 0.001) and OSA-COPD overlap (− 12.3%, p = 0.02) compared with HNS. There were no differences when comparing sRAGE plasma levels between overlap patients and those with OSA or COPD alone. At follow-up, sRAGE levels did not change significantly in healthy subjects, COPD and OSA or OSA-COPD overlap nontreated with continuous positive airway pressure (CPAP). Moreover, in patients with OSA and OSA-COPD overlap who were treated with CPAP, sRAGE increased significantly. Conclusions The levels of sRAGE are reduced in COPD and OSA. Treatment with CPAP appears to improve sRAGE levels in patients with OSA who also had COPD.https://doi.org/10.1186/s12931-022-02092-9sRAGESmokersChronic obstructive pulmonary diseaseObstructive sleep apnoea |
| spellingShingle | Marta Marin-Oto David Sanz-Rubio Fernando Santamaría-Martos Ivan Benitez Ana L. Simon Marta Forner Pablo Cubero Ana Gil Manuel Sanchez-de-laTorre Ferran Barbe José M. Marin Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea Respiratory Research sRAGE Smokers Chronic obstructive pulmonary disease Obstructive sleep apnoea |
| title | Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea |
| title_full | Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea |
| title_fullStr | Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea |
| title_full_unstemmed | Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea |
| title_short | Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea |
| title_sort | soluble rage in copd with or without coexisting obstructive sleep apnoea |
| topic | sRAGE Smokers Chronic obstructive pulmonary disease Obstructive sleep apnoea |
| url | https://doi.org/10.1186/s12931-022-02092-9 |
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