Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04685-9 |
| _version_ | 1818342547501613056 |
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| author | Benedikt Strunz Julia Hengst Katja Deterding Michael P. Manns Markus Cornberg Hans-Gustaf Ljunggren Heiner Wedemeyer Niklas K. Björkström |
| author_facet | Benedikt Strunz Julia Hengst Katja Deterding Michael P. Manns Markus Cornberg Hans-Gustaf Ljunggren Heiner Wedemeyer Niklas K. Björkström |
| author_sort | Benedikt Strunz |
| collection | DOAJ |
| description | Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity. |
| first_indexed | 2024-12-13T16:16:25Z |
| format | Article |
| id | doaj.art-7563551b3be94ca4b9ea985c35f676c8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:16:25Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7563551b3be94ca4b9ea985c35f676c82022-12-21T23:38:49ZengNature PortfolioNature Communications2041-17232018-06-019111210.1038/s41467-018-04685-9Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversityBenedikt Strunz0Julia Hengst1Katja Deterding2Michael P. Manns3Markus Cornberg4Hans-Gustaf Ljunggren5Heiner Wedemeyer6Niklas K. Björkström7Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical SchoolDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeNatural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.https://doi.org/10.1038/s41467-018-04685-9 |
| spellingShingle | Benedikt Strunz Julia Hengst Katja Deterding Michael P. Manns Markus Cornberg Hans-Gustaf Ljunggren Heiner Wedemeyer Niklas K. Björkström Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity Nature Communications |
| title | Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity |
| title_full | Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity |
| title_fullStr | Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity |
| title_full_unstemmed | Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity |
| title_short | Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity |
| title_sort | chronic hepatitis c virus infection irreversibly impacts human natural killer cell repertoire diversity |
| url | https://doi.org/10.1038/s41467-018-04685-9 |
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