Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam
Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment <i>Penicillium</i> species collected in Vietnam yielded ten secondary metabolites, including s...
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| Format: | Article |
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MDPI AG
2019-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/21/3830 |
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| author | Hong Minh Thi Le Quynh Thi Do Mai Huong Thi Doan Quyen Thi Vu Mai Anh Nguyen Thu Huyen Thi Vu Hai Dang Nguyen Nguyen Thi Thuy Duong Manh Hung Tran Van Minh Chau Van Cuong Pham |
| author_facet | Hong Minh Thi Le Quynh Thi Do Mai Huong Thi Doan Quyen Thi Vu Mai Anh Nguyen Thu Huyen Thi Vu Hai Dang Nguyen Nguyen Thi Thuy Duong Manh Hung Tran Van Minh Chau Van Cuong Pham |
| author_sort | Hong Minh Thi Le |
| collection | DOAJ |
| description | Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment <i>Penicillium</i> species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (<b>1</b>), 3-indolecarbaldehyde (<b>2</b>), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (<b>3</b>), 2-[(2<i>R</i>-hydroxypropanoyl)amino]benzamide (<b>4</b>), 4-hydroxybenzandehyde (<b>5</b>), chrysogine (<b>6</b>), 3-acetyl-4-hydroxycinnoline (<b>7</b>), acid 1H-indole-3-acetic (<b>8</b>), cyclo (Tyr-Trp) (<b>9</b>), and 2’,3’-dihydrosorbicillin (<b>10</b>). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (<b>3</b>) showed a strong inhibitory effect against <i>Enterococcus faecalis</i> with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2<i>R</i>-hydroxypropanoyl)amino]benzamide (<b>4</b>) and 4-hydroxybenzandehyde (<b>5</b>) selectively inhibited <i>E. coli</i> with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2’,3’-Dihydrosorbicillin (<b>10</b>) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%). |
| first_indexed | 2024-12-19T08:56:52Z |
| format | Article |
| id | doaj.art-756444d7a9c24eacb01f0d8964dc2fd9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T08:56:52Z |
| publishDate | 2019-10-01 |
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| series | Molecules |
| spelling | doaj.art-756444d7a9c24eacb01f0d8964dc2fd92022-12-21T20:28:36ZengMDPI AGMolecules1420-30492019-10-012421383010.3390/molecules24213830molecules24213830Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, VietnamHong Minh Thi Le0Quynh Thi Do1Mai Huong Thi Doan2Quyen Thi Vu3Mai Anh Nguyen4Thu Huyen Thi Vu5Hai Dang Nguyen6Nguyen Thi Thuy Duong7Manh Hung Tran8Van Minh Chau9Van Cuong Pham10Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamUniversity of Science and Technology of Hanoi (U.S.T.H.), Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamBiomedical Science Department, Institute for Research & Executive Education (V.N.U.K.), The University of Danang, 158A Le Loi, Hai Chau District, Danang City 551000, VietnamBiomedical Science Department, Institute for Research & Executive Education (V.N.U.K.), The University of Danang, 158A Le Loi, Hai Chau District, Danang City 551000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, VietnamMarine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment <i>Penicillium</i> species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (<b>1</b>), 3-indolecarbaldehyde (<b>2</b>), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (<b>3</b>), 2-[(2<i>R</i>-hydroxypropanoyl)amino]benzamide (<b>4</b>), 4-hydroxybenzandehyde (<b>5</b>), chrysogine (<b>6</b>), 3-acetyl-4-hydroxycinnoline (<b>7</b>), acid 1H-indole-3-acetic (<b>8</b>), cyclo (Tyr-Trp) (<b>9</b>), and 2’,3’-dihydrosorbicillin (<b>10</b>). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (<b>3</b>) showed a strong inhibitory effect against <i>Enterococcus faecalis</i> with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2<i>R</i>-hydroxypropanoyl)amino]benzamide (<b>4</b>) and 4-hydroxybenzandehyde (<b>5</b>) selectively inhibited <i>E. coli</i> with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2’,3’-Dihydrosorbicillin (<b>10</b>) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).https://www.mdpi.com/1420-3049/24/21/3830marine fungi <i>penicillium</i> sp.3-acetyl-4-hydroxycinnoline4-hydroxybenzandehitantimicrobiologyα-glucosidase |
| spellingShingle | Hong Minh Thi Le Quynh Thi Do Mai Huong Thi Doan Quyen Thi Vu Mai Anh Nguyen Thu Huyen Thi Vu Hai Dang Nguyen Nguyen Thi Thuy Duong Manh Hung Tran Van Minh Chau Van Cuong Pham Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam Molecules marine fungi <i>penicillium</i> sp. 3-acetyl-4-hydroxycinnoline 4-hydroxybenzandehit antimicrobiology α-glucosidase |
| title | Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam |
| title_full | Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam |
| title_fullStr | Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam |
| title_full_unstemmed | Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam |
| title_short | Chemical Composition and Biological Activities of Metabolites from the Marine Fungi <em>Penicillium</em> sp. Isolated from Sediments of Co To Island, Vietnam |
| title_sort | chemical composition and biological activities of metabolites from the marine fungi em penicillium em sp isolated from sediments of co to island vietnam |
| topic | marine fungi <i>penicillium</i> sp. 3-acetyl-4-hydroxycinnoline 4-hydroxybenzandehit antimicrobiology α-glucosidase |
| url | https://www.mdpi.com/1420-3049/24/21/3830 |
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