Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020
Background and purpose: Infants with persistent pulmonary hypertension (PPHN) are readmitted to hospital three times more than other infants or die after discharge. The disease imposes a high cost on families and health systems. In this study, for the first time, the prevalence of PPHN and associate...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2022-07-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-17072-en.html |
| _version_ | 1797893229227540480 |
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| author | Niloofar Kalantai nejad Mohammadmehdi Bagheri Hossein Ghaedamini Mahdi Kalantari nejad Raheleh Amirzadeh Fatemeh Yazdi Elmira Salari |
| author_facet | Niloofar Kalantai nejad Mohammadmehdi Bagheri Hossein Ghaedamini Mahdi Kalantari nejad Raheleh Amirzadeh Fatemeh Yazdi Elmira Salari |
| author_sort | Niloofar Kalantai nejad |
| collection | DOAJ |
| description | Background and purpose: Infants with persistent pulmonary hypertension (PPHN) are readmitted to hospital three times more than other infants or die after discharge. The disease imposes a high cost on families and health systems. In this study, for the first time, the prevalence of PPHN and associated factors were investigated in mature neonates born in southeast of Iran.
Materials and methods: In this cross-sectional study, the clinical records of 1859 infants born in Kerman Afzalipour Hospital, 2020 were reviewed. Infants hospitalized from delivery, congenital heart disease, other differential diagnoses of PPHN, and evidence of genetic diseases were excluded from the study. Then, mature infants with clinical evidence of PPHN underwent Doppler echocardiography to confirm the final diagnosis. Information about pregnancy, childbirth, infant gender, birth, 1-minute and 5-minute Apgar scores, and advanced respiratory support were also obtained. Data were analyzed by SPSS V25.
Results: Out of 229 neonates meeting the inclusion criteria, 31 (11.9%) had PPHN. Signification relationship was observed between frequency of PPHN and cesarean delivery and 5-minute minute Apgar score (P<0.05). But, no significant association was found between developing PPHN and other maternal or neonatal factors (P>0.05). The mean parameters of PPHN, including tricuspid annular plane systolic excursion (TAPSE), tricuspid regurgitation rate, mean pulmonary artery pressure, and pulmonary artery diameter were significantly higher in infants delivered by cesarean section than those born by normal vaginal delivery group (P<0.05).
Conclusion: Further multicenter studies with larger sample size over a longer period of time are suggested in southeast of Iran to elicit clear explanations on the association between PPHN and maternal, fetal, and neonatal factors. |
| first_indexed | 2024-04-10T06:49:31Z |
| format | Article |
| id | doaj.art-7564467a95204b48a98693d22a784ff8 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:31Z |
| publishDate | 2022-07-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-7564467a95204b48a98693d22a784ff82023-02-28T08:48:56ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-07-01322107179Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020Niloofar Kalantai nejad0Mohammadmehdi Bagheri1Hossein Ghaedamini2Mahdi Kalantari nejad3Raheleh Amirzadeh4Fatemeh Yazdi5Elmira Salari6 Resident in Pediatric Diseases, School of Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran Assistant Professor, Department of Pediatrics, School of Medicine, Physiology Research Center, Neuropharmacology Research Institute, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran Resident in General Surgery, School of Medicine, Golestan Hospital, Jundishapur University of Medical Sciences, Ahvaz, Iran General Practitioner, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran MSc in Epidemiology, Research Center for Social Determinants of Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Resident in Pediatric Diseases, School of Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran Resident in Pediatric Diseases, School of Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran Background and purpose: Infants with persistent pulmonary hypertension (PPHN) are readmitted to hospital three times more than other infants or die after discharge. The disease imposes a high cost on families and health systems. In this study, for the first time, the prevalence of PPHN and associated factors were investigated in mature neonates born in southeast of Iran. Materials and methods: In this cross-sectional study, the clinical records of 1859 infants born in Kerman Afzalipour Hospital, 2020 were reviewed. Infants hospitalized from delivery, congenital heart disease, other differential diagnoses of PPHN, and evidence of genetic diseases were excluded from the study. Then, mature infants with clinical evidence of PPHN underwent Doppler echocardiography to confirm the final diagnosis. Information about pregnancy, childbirth, infant gender, birth, 1-minute and 5-minute Apgar scores, and advanced respiratory support were also obtained. Data were analyzed by SPSS V25. Results: Out of 229 neonates meeting the inclusion criteria, 31 (11.9%) had PPHN. Signification relationship was observed between frequency of PPHN and cesarean delivery and 5-minute minute Apgar score (P<0.05). But, no significant association was found between developing PPHN and other maternal or neonatal factors (P>0.05). The mean parameters of PPHN, including tricuspid annular plane systolic excursion (TAPSE), tricuspid regurgitation rate, mean pulmonary artery pressure, and pulmonary artery diameter were significantly higher in infants delivered by cesarean section than those born by normal vaginal delivery group (P<0.05). Conclusion: Further multicenter studies with larger sample size over a longer period of time are suggested in southeast of Iran to elicit clear explanations on the association between PPHN and maternal, fetal, and neonatal factors.http://jmums.mazums.ac.ir/article-1-17072-en.htmlprevalencepersistent pulmonary hypertension of the newbornterm birthiran |
| spellingShingle | Niloofar Kalantai nejad Mohammadmehdi Bagheri Hossein Ghaedamini Mahdi Kalantari nejad Raheleh Amirzadeh Fatemeh Yazdi Elmira Salari Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020 Journal of Mazandaran University of Medical Sciences prevalence persistent pulmonary hypertension of the newborn term birth iran |
| title | Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020 |
| title_full | Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020 |
| title_fullStr | Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020 |
| title_full_unstemmed | Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020 |
| title_short | Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020 |
| title_sort | prevalence of persistent pulmonary hypertension of the newborn and associated factors in term neonates born in southeast of iran 2020 |
| topic | prevalence persistent pulmonary hypertension of the newborn term birth iran |
| url | http://jmums.mazums.ac.ir/article-1-17072-en.html |
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