Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area
Background: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs). Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ukrainian Society of Ophthalmologists
2023-11-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://ua.ozhurnal.com/index.php/files/article/view/65 |
| _version_ | 1797641343349030912 |
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| author | Yu. M. Samchenko S. M. Dybkova Anatolii Maletskyi L. O. Kernosenko T. G. Gruzina N. O. Pasmurtseva L. S. Rieznichenko O. B. Liutko K. V. Vitrak N. M. Bigun P. V. Vorotytskyi I. Ie. Mamyshev |
| author_facet | Yu. M. Samchenko S. M. Dybkova Anatolii Maletskyi L. O. Kernosenko T. G. Gruzina N. O. Pasmurtseva L. S. Rieznichenko O. B. Liutko K. V. Vitrak N. M. Bigun P. V. Vorotytskyi I. Ie. Mamyshev |
| author_sort | Yu. M. Samchenko |
| collection | DOAJ |
| description | Background: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs).
Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area.
Material and Methods: A 30% aqueous solution of albucide was used in the study. Antimicrobial activity of synthesized hydrogels was determined using Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29213, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains.
Results: All the synthesized samples of orbital hydrogel implants were sterile.
The synthesized hydrogels and hydrogel nanocomposites with incorporated Au nanoparticles demonstrated bacteriostatic effects against E. Coli ATCC 25922, E. Faecalis ATCC 29213, and S. Aureus ATCC 25923 strains, and bactericidal effects against P. Aeruginosa ATCC 27853 strain. This study also demonstrated marked bactericidal effects of hybrid hydrogel implants incorporating both Au nanoparticles and albucide.
Conclusion: Orbital hydrogel implants were found to be sterile after being sealed into polypropylene bags and steam sterilized at 121 °C for 20 minutes. Our findings of bacteriostatic and bactericidal effects of the synthesized hydrogels and hydrogel nanocomposites containing Au nanoparticles and albucide against bacterial strains of interest will allow for the absence of, or low probability of bacterial contamination in applications of these hydrogels in implants. |
| first_indexed | 2024-03-11T13:44:16Z |
| format | Article |
| id | doaj.art-75658cd6b21c45a59490a1688667ebf0 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-11T13:44:16Z |
| publishDate | 2023-11-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-75658cd6b21c45a59490a1688667ebf02023-11-02T10:51:22ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402023-11-0152733https://doi.org/10.31288/oftalmolzh202352733Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital areaYu. M. Samchenko0S. M. Dybkova1Anatolii Maletskyi2https://orcid.org/0000-0002-7135-5218L. O. Kernosenko3T. G. Gruzina4N. O. Pasmurtseva5L. S. Rieznichenko6O. B. Liutko7K. V. Vitrak8N. M. Bigun9P. V. Vorotytskyi10I. Ie. Mamyshev11F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineF.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineSI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"F.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineF.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineF.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineF.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineSI “The Institute of Traumatology and Orthopedics” by NAMS of Ukraine"SI “The Institute of Traumatology and Orthopedics” by NAMS of Ukraine"Lviv Regional Clinical HospitalF.D.Ovcharenko Institute for Biocolloidal Chemistry, NAS of UkraineInstitute of Geological Science of Ukraine National Science AcademyBackground: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs). Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area. Material and Methods: A 30% aqueous solution of albucide was used in the study. Antimicrobial activity of synthesized hydrogels was determined using Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29213, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains. Results: All the synthesized samples of orbital hydrogel implants were sterile. The synthesized hydrogels and hydrogel nanocomposites with incorporated Au nanoparticles demonstrated bacteriostatic effects against E. Coli ATCC 25922, E. Faecalis ATCC 29213, and S. Aureus ATCC 25923 strains, and bactericidal effects against P. Aeruginosa ATCC 27853 strain. This study also demonstrated marked bactericidal effects of hybrid hydrogel implants incorporating both Au nanoparticles and albucide. Conclusion: Orbital hydrogel implants were found to be sterile after being sealed into polypropylene bags and steam sterilized at 121 °C for 20 minutes. Our findings of bacteriostatic and bactericidal effects of the synthesized hydrogels and hydrogel nanocomposites containing Au nanoparticles and albucide against bacterial strains of interest will allow for the absence of, or low probability of bacterial contamination in applications of these hydrogels in implants.https://ua.ozhurnal.com/index.php/files/article/view/65hydrogel implants containing au nanoparticles and albucideantimicrobial effectsreconstructive surgery in the orbit and periorbital area |
| spellingShingle | Yu. M. Samchenko S. M. Dybkova Anatolii Maletskyi L. O. Kernosenko T. G. Gruzina N. O. Pasmurtseva L. S. Rieznichenko O. B. Liutko K. V. Vitrak N. M. Bigun P. V. Vorotytskyi I. Ie. Mamyshev Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area Journal of Ophthalmology hydrogel implants containing au nanoparticles and albucide antimicrobial effects reconstructive surgery in the orbit and periorbital area |
| title | Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area |
| title_full | Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area |
| title_fullStr | Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area |
| title_full_unstemmed | Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area |
| title_short | Antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area |
| title_sort | antimicrobial effects of hydrogel implants incorporating gold nanopartucles and albucide and developed for reconstructive surgery in the orbit and periorbital area |
| topic | hydrogel implants containing au nanoparticles and albucide antimicrobial effects reconstructive surgery in the orbit and periorbital area |
| url | https://ua.ozhurnal.com/index.php/files/article/view/65 |
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