Au-24 as a potential thioredoxin reductase inhibitor in hepatocellular carcinoma cells

Au-24 as a potential thioredoxin reductase inhibitor in hepatocellular carcinoma cells

A novel TrxR inhibitor Au-24 and its inhibitory ability to hepatocellular carcinoma in vitro and in vivo is reported herein. Au-24 can suppress HepG2 cells from proliferating by lowering mitochondrial membrane potential (MMP) and increasing reactive oxygen species (ROS) levels, resulting in oxidativ...

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Bibliographic Details
Main Authors: Gaopan Dong, Xiaohan Ye, Shumei Wang, Wenhua Li, Rong Cai, Lupei Du, Xiaodong Shi, Minyong Li
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Thioredoxin reductase (TrxR) inhibitor
Signaling pathways
Apoptosis
Hepatocellular carcinoma (HCC)
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000585

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