H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis summarize the difference in the methylation of the <i>H19</i> gene in patients with abnormal versus normal conventional sperm parameters. It also evaluates the effects of age and sperm concentration on <i>H19</i> methylation in spermat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7224 |
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| author | Rossella Cannarella Andrea Crafa Federica Barbagallo Scott D. Lundy Sandro La Vignera Rosita A. Condorelli Aldo E. Calogero |
| author_facet | Rossella Cannarella Andrea Crafa Federica Barbagallo Scott D. Lundy Sandro La Vignera Rosita A. Condorelli Aldo E. Calogero |
| author_sort | Rossella Cannarella |
| collection | DOAJ |
| description | This systematic review and meta-analysis summarize the difference in the methylation of the <i>H19</i> gene in patients with abnormal versus normal conventional sperm parameters. It also evaluates the effects of age and sperm concentration on <i>H19</i> methylation in spermatozoa using meta-regression analysis. It was performed according to the MOOSE guidelines for meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The quality of the evidence reported in the studies included was assessed using the Cambridge Quality Checklists. A total of 11 articles met our inclusion criteria. Quantitative analysis showed that <i>H19</i> methylation levels were significantly lower in the group of infertile patients than in fertile controls. The reduction in methylation was much more pronounced in patients with oligozoospermia (alone or associated with other sperm parameter abnormalities) and in those with recurrent pregnancy loss. Meta-regression analysis showed the results to be independent of both patient age and sperm concentration. Therefore, the <i>H19</i> methylation pattern should be evaluated among couples accessing assisted reproductive techniques (ART), in order to gain prognostic information on ART outcome and offspring health. |
| first_indexed | 2024-03-11T04:56:09Z |
| format | Article |
| id | doaj.art-7566e14585a248d38b4795f9ceaee359 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:09Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7566e14585a248d38b4795f9ceaee3592023-11-17T19:37:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248722410.3390/ijms24087224H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-AnalysisRossella Cannarella0Andrea Crafa1Federica Barbagallo2Scott D. Lundy3Sandro La Vignera4Rosita A. Condorelli5Aldo E. Calogero6Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyGlickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH 44125, USADepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyThis systematic review and meta-analysis summarize the difference in the methylation of the <i>H19</i> gene in patients with abnormal versus normal conventional sperm parameters. It also evaluates the effects of age and sperm concentration on <i>H19</i> methylation in spermatozoa using meta-regression analysis. It was performed according to the MOOSE guidelines for meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The quality of the evidence reported in the studies included was assessed using the Cambridge Quality Checklists. A total of 11 articles met our inclusion criteria. Quantitative analysis showed that <i>H19</i> methylation levels were significantly lower in the group of infertile patients than in fertile controls. The reduction in methylation was much more pronounced in patients with oligozoospermia (alone or associated with other sperm parameter abnormalities) and in those with recurrent pregnancy loss. Meta-regression analysis showed the results to be independent of both patient age and sperm concentration. Therefore, the <i>H19</i> methylation pattern should be evaluated among couples accessing assisted reproductive techniques (ART), in order to gain prognostic information on ART outcome and offspring health.https://www.mdpi.com/1422-0067/24/8/7224H19methylationoligozoospermiainfertilityepigenetic |
| spellingShingle | Rossella Cannarella Andrea Crafa Federica Barbagallo Scott D. Lundy Sandro La Vignera Rosita A. Condorelli Aldo E. Calogero H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis International Journal of Molecular Sciences H19 methylation oligozoospermia infertility epigenetic |
| title | H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis |
| title_full | H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis |
| title_fullStr | H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis |
| title_short | H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis |
| title_sort | h19 sperm methylation in male infertility a systematic review and meta analysis |
| topic | H19 methylation oligozoospermia infertility epigenetic |
| url | https://www.mdpi.com/1422-0067/24/8/7224 |
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