p66Shc in Cardiovascular Pathology

p66Shc in Cardiovascular Pathology

p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc’s connections to reactive oxygen species, expression, localization, and discuss p66Shc signaling and mitochondrial functions. E...

Full description

Bibliographic Details
Main Authors:	Landon Haslem, Jennifer M. Hays, Franklin A. Hays
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Cells
Subjects:	mitochondrial dysfunction p66Shc apoptosis ischemia/reperfusion myocardial infarction ROS
Online Access:	https://www.mdpi.com/2073-4409/11/11/1855

Similar Items

P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology
by: Landon Haslem, et al.
Published: (2022-11-01)

p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis
by: Shin HJ, et al.
Published: (2020-04-01)

Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC
by: Anna Onnis, et al.
Published: (2020-03-01)

Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis
by: Lili Liang, et al.
Published: (2016-04-01)

Lack of Contribution of p66shc and Its Mitochondrial Translocation to Ischemia-Reperfusion Injury and Cardioprotection by Ischemic Preconditioning
by: Kerstin Boengler, et al.
Published: (2017-10-01)

The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma
by: Gang Peng, et al.
Published: (2024-05-01)

P66Shc expression in diabetic rat retina
by: Ming-Hui Zhao, et al.
Published: (2018-02-01)

The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E‐transformed cells
by: Tobias Furlan, et al.
Published: (2018-06-01)

p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation
by: Ludovica Lopresti, et al.
Published: (2024-01-01)

Rigosertib-Activated JNK1/2 Eliminate Tumor Cells through p66Shc Activation
by: Julia K. Günther, et al.
Published: (2020-05-01)

Grape seed proanthocyanidin extract targets p66Shc to regulate mitochondrial biogenesis and dynamics in diabetic kidney disease
by: Yiyun Song, et al.
Published: (2023-01-01)

SAHA inhibits lung fibroblast activation by increasing p66Shc expression epigenetically
by: Yiheng Dong, et al.
Published: (2024-12-01)

Carnosic Acid Mitigates Early Brain Injury After Subarachnoid Hemorrhage: Possible Involvement of the SIRT1/p66shc Signaling Pathway
by: Lingfang Teng, et al.
Published: (2019-03-01)

A Cross-Sectional Study of p66Shc Gene Expression in Liquid Biopsy of Diabetic Patients. Is it Possible to Predict the Onset of Renal Disease?
by: Diogo P. Simões, et al.
Published: (2023-02-01)

Construction of p66Shc gene interfering lentivirus vectors and its affections on alveolar epithelial cells apoptosis induced by hyperoxia
by: Zhang C, et al.
Published: (2016-08-01)

Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation
by: Yanmin Jiang, et al.
Published: (2024-12-01)

Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis
by: Daojuan Wang, et al.
Published: (2020-02-01)

p66ShcA functions as a contextual promoter of breast cancer metastasis
by: Kyle Lewis, et al.
Published: (2020-01-01)

Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges
by: Michael eForte, et al.
Published: (2012-07-01)

High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
by: Lulu Ji, et al.
Published: (2024-04-01)

p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-κB
by: Vanessa Tatangelo, et al.
Published: (2022-06-01)

p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress
by: Kyle Lewis, et al.
Published: (2024-04-01)

Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
by: Hao C, et al.
Published: (2019-09-01)

SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc
by: Tao Jiang, et al.
Published: (2023-04-01)

Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system
by: Hannah N. Robeson, et al.
Published: (2019-12-01)

SIRT6 reduces the symptoms of premature ovarian failure and alleviates oxidative stress and apoptosis in granulosa cells by degrading p66SHC via H3K9AC
by: Chuan Shen, et al.
Published: (2023-12-01)

Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas
by: Rafia A. Baba, et al.
Published: (2024-01-01)

Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells
by: Xiaohui Zhou, et al.

MITOCHONDRIAL DYSFUNCTION AS POSSIBLE CAUSE OF IMPAIRED FOLLICULAR DEVELOPMENT
by: A. A. Pozdnyakova, et al.
Published: (2016-06-01)

Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion Injury
by: Lihao He, et al.
Published: (2022-07-01)

Quercetin inhibits cardiomyocyte apoptosis via Sirt3/SOD2/mitochondrial reactive oxygen species during myocardial ischemia–reperfusion injury
by: Da Xiong, et al.
Published: (2024-11-01)

Shc3 over-expression inhibits apoptosis of HCC cells and is involved in drug resistance
by: ZHANG Xin-ran, ZHANG Yi, GAO Hui-er, QIANG Zhao-yan, LI Yong-mei
Published: (2020-04-01)

Protective Effects of Curcumin against Sodium Arsenite-induced Ovarian Oxidative Injury in a Mouse Model
by: Xiao-Ning Wang, et al.
Published: (2017-01-01)

Overexpression of TIMP3 Protects Against Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Apoptosis Through ROS/Mapks Pathway
by: Hui Liu, et al.
Published: (2017-11-01)

Platelet Contributions to Myocardial Ischemia/Reperfusion Injury
by: Nancy Schanze, et al.
Published: (2019-06-01)

Benefits of the SHC System on Publication Management and Promotion of Sports Actor Services
by: Sapto Adi, et al.
Published: (2022-04-01)

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis
by: Kimmy eSu, et al.
Published: (2013-07-01)

Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction
by: Tianyu Shen, et al.
Published: (2022-03-01)

Allicin attenuates myocardial apoptosis, inflammation and mitochondrial injury during hypoxia-reoxygenation: an in vitro study
by: Xinyi Deng, et al.
Published: (2021-04-01)

Arginase-II Deficiency Extends Lifespan in Mice
by: Yuyan Xiong, et al.
Published: (2017-09-01)