The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice
Many preclinical studies of infectious diseases have neglected experimental designs that evaluate potential differences related to sex with a concomitant over-reliance on male model systems. Hence, the NIH implemented a monitoring system for sex inclusion in preclinical studies. Methods: Per this ma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/10/1101 |
| _version_ | 1797472219460272128 |
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| author | Nikeya L. Macioce-Tisdale Alan Ashbaugh Keeley Hendrix Margaret S. Collins Aleksey Porollo Melanie T. Cushion |
| author_facet | Nikeya L. Macioce-Tisdale Alan Ashbaugh Keeley Hendrix Margaret S. Collins Aleksey Porollo Melanie T. Cushion |
| author_sort | Nikeya L. Macioce-Tisdale |
| collection | DOAJ |
| description | Many preclinical studies of infectious diseases have neglected experimental designs that evaluate potential differences related to sex with a concomitant over-reliance on male model systems. Hence, the NIH implemented a monitoring system for sex inclusion in preclinical studies. Methods: Per this mandate, we examined the lung burdens of <i>Pneumocystis murina</i> infection in three mouse strains in both male and female animals at early, mid, and late time points. Results: Females in each strain had higher infection burdens compared to males at the later time points. Conclusion: Females should be included in experimental models studying <i>Pneumocystis</i> spp. |
| first_indexed | 2024-03-09T20:00:04Z |
| format | Article |
| id | doaj.art-756af2c811d54a829711c5c503384b7e |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T20:00:04Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-756af2c811d54a829711c5c503384b7e2023-11-24T00:47:57ZengMDPI AGJournal of Fungi2309-608X2022-10-01810110110.3390/jof8101101The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in MiceNikeya L. Macioce-Tisdale0Alan Ashbaugh1Keeley Hendrix2Margaret S. Collins3Aleksey Porollo4Melanie T. Cushion5Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USACenter for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USAMany preclinical studies of infectious diseases have neglected experimental designs that evaluate potential differences related to sex with a concomitant over-reliance on male model systems. Hence, the NIH implemented a monitoring system for sex inclusion in preclinical studies. Methods: Per this mandate, we examined the lung burdens of <i>Pneumocystis murina</i> infection in three mouse strains in both male and female animals at early, mid, and late time points. Results: Females in each strain had higher infection burdens compared to males at the later time points. Conclusion: Females should be included in experimental models studying <i>Pneumocystis</i> spp.https://www.mdpi.com/2309-608X/8/10/1101<i>Pneumocystis</i>pneumoniaAIDS-relatedsex differencesexperimental design |
| spellingShingle | Nikeya L. Macioce-Tisdale Alan Ashbaugh Keeley Hendrix Margaret S. Collins Aleksey Porollo Melanie T. Cushion The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice Journal of Fungi <i>Pneumocystis</i> pneumonia AIDS-related sex differences experimental design |
| title | The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice |
| title_full | The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice |
| title_fullStr | The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice |
| title_full_unstemmed | The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice |
| title_short | The Effects of Sex and Strain on <i>Pneumocystis murina</i> Fungal Burdens in Mice |
| title_sort | effects of sex and strain on i pneumocystis murina i fungal burdens in mice |
| topic | <i>Pneumocystis</i> pneumonia AIDS-related sex differences experimental design |
| url | https://www.mdpi.com/2309-608X/8/10/1101 |
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