A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association
To highlight a possible causal relationship between thyrotoxicosis and cerebellar syndrome, here we present a hitherto undescribed association. Clinical case description. A 16-year-old male presented to hospital following an episode of unusual behavior on the football pitch, where he was witnessed a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2014-09-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2014.440 |
| _version_ | 1811282263505108992 |
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| author | Tarik Abdelkareim Elhadd Kathryn Linton Caoihme McCoy Subrata Saha Roger Holden |
| author_facet | Tarik Abdelkareim Elhadd Kathryn Linton Caoihme McCoy Subrata Saha Roger Holden |
| author_sort | Tarik Abdelkareim Elhadd |
| collection | DOAJ |
| description | To highlight a possible causal relationship between thyrotoxicosis and cerebellar syndrome, here we present a hitherto undescribed association. Clinical case description. A 16-year-old male presented to hospital following an episode of unusual behavior on the football pitch, where he was witnessed as grossly ataxic by his teammates. The assessment demonstrated marked cerebellar signs on examination but no other neurological deficit. The investigation showed the evidence of biochemical thyrotoxicosis with free T4 at 37 pmol/L (normal reference range: 11–27) and thyrotropin (TSH) <0.003 mU/L. Following admission, full investigations including computed tomographic brain scan with contrast, lumbar puncture with cerebrospinal fluid examination, magnetic resonance imaging, and magnetic resonance angiography did not reveal abnormalities. He was initiated on carbimazole 40 mg every day. Thyroid ultrasonography revealed a goiter with increased blood flow, and his thyroid antibodies showed positive thyroid peroxidase antibodies but negative TSH receptor antibodies. Electroencephalogram did not reveal any abnormalities. His neurological disability resolved completely after his thyroid function normalized. The association of cerebellar syndromes is well described with hypothyroidism; however, it is hitherto undescribed with thyrotoxicosis. The causal relationship is plausible because alternative etiologies were excluded, and the normalization of thyroid function with treatment was coupled with complete resolution of the neurological syndrome. Cerebellar syndromes may well be one of the presenting features of thyrotoxicosis, and this should be in the list of its differential diagnosis. |
| first_indexed | 2024-04-13T01:49:32Z |
| format | Article |
| id | doaj.art-756b01bf9af04ee894ae7f715c025c79 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-04-13T01:49:32Z |
| publishDate | 2014-09-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-756b01bf9af04ee894ae7f715c025c792022-12-22T03:07:55ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662014-09-0134544044310.5144/0256-4947.2014.440asm-5-440A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible associationTarik Abdelkareim Elhadd0Kathryn Linton1Caoihme McCoy2Subrata Saha3Roger Holden4From the Department of Endocrinology, Lincoln County Hospital, Lincolnshire, United KingdomFrom the Department of Medicine, Dumfries & Galloway Royal Infirmary, Dumfries, United KingdomFrom the Department of Medicine, Dumfries & Galloway Royal Infirmary, Dumfries, United KingdomFrom the Department of Medicine, Dumfries & Galloway Royal Infirmary, Dumfries, United KingdomFrom the Department of Medicine, Dumfries & Galloway Royal Infirmary, Dumfries, United KingdomTo highlight a possible causal relationship between thyrotoxicosis and cerebellar syndrome, here we present a hitherto undescribed association. Clinical case description. A 16-year-old male presented to hospital following an episode of unusual behavior on the football pitch, where he was witnessed as grossly ataxic by his teammates. The assessment demonstrated marked cerebellar signs on examination but no other neurological deficit. The investigation showed the evidence of biochemical thyrotoxicosis with free T4 at 37 pmol/L (normal reference range: 11–27) and thyrotropin (TSH) <0.003 mU/L. Following admission, full investigations including computed tomographic brain scan with contrast, lumbar puncture with cerebrospinal fluid examination, magnetic resonance imaging, and magnetic resonance angiography did not reveal abnormalities. He was initiated on carbimazole 40 mg every day. Thyroid ultrasonography revealed a goiter with increased blood flow, and his thyroid antibodies showed positive thyroid peroxidase antibodies but negative TSH receptor antibodies. Electroencephalogram did not reveal any abnormalities. His neurological disability resolved completely after his thyroid function normalized. The association of cerebellar syndromes is well described with hypothyroidism; however, it is hitherto undescribed with thyrotoxicosis. The causal relationship is plausible because alternative etiologies were excluded, and the normalization of thyroid function with treatment was coupled with complete resolution of the neurological syndrome. Cerebellar syndromes may well be one of the presenting features of thyrotoxicosis, and this should be in the list of its differential diagnosis.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2014.440 |
| spellingShingle | Tarik Abdelkareim Elhadd Kathryn Linton Caoihme McCoy Subrata Saha Roger Holden A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association Annals of Saudi Medicine |
| title | A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association |
| title_full | A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association |
| title_fullStr | A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association |
| title_full_unstemmed | A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association |
| title_short | A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association |
| title_sort | hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man a plausible association |
| url | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2014.440 |
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