Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy
Neonatal brain injury leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a painful and functionally debilitating movement disorder. Rare monogenic etiologies of dystonia have been associated with striatal cholinergic interneuron (ChI) pathology. However it is unclear whet...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-10-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612030320X |
| _version_ | 1818645486303707136 |
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| author | Sushma Gandham Yearam Tak Bhooma R. Aravamuthan |
| author_facet | Sushma Gandham Yearam Tak Bhooma R. Aravamuthan |
| author_sort | Sushma Gandham |
| collection | DOAJ |
| description | Neonatal brain injury leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a painful and functionally debilitating movement disorder. Rare monogenic etiologies of dystonia have been associated with striatal cholinergic interneuron (ChI) pathology. However it is unclear whether striatal ChI pathology is also associated with dystonia following neonatal brain injury. We used unbiased stereology to estimate striatal ChI and parvalbumin-positive GABAergic interneuron (PVI) numbers in a rodent model of neonatal brain injury that demonstrates electrophysiological markers of dystonia and spasticity. Striatal ChI numbers are increased following neonatal brain injury while PVI numbers are unchanged. These numbers do not correlate with electrophysiologic measures of dystonia severity. This suggests that striatal ChI pathology, though present, may not be the primary pathophysiologic contributor to dystonia following neonatal brain injury. Increased striatal ChI numbers could instead represent a passenger or protective phenomenon in the setting of dystonic CP. |
| first_indexed | 2024-12-17T00:31:30Z |
| format | Article |
| id | doaj.art-756bbabc633b40d1a93b8373a2f1222c |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T00:31:30Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-756bbabc633b40d1a93b8373a2f1222c2022-12-21T22:10:16ZengElsevierNeurobiology of Disease1095-953X2020-10-01144105045Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsySushma Gandham0Yearam Tak1Bhooma R. Aravamuthan2Department of Neurology, Washington University School of Medicine, St. Louis, MO, USASt. Louis College of Pharmacy, St. Louis, MO, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Corresponding author at: Department of Neurology, Division of Pediatric Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO 63110-1093, USA.Neonatal brain injury leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a painful and functionally debilitating movement disorder. Rare monogenic etiologies of dystonia have been associated with striatal cholinergic interneuron (ChI) pathology. However it is unclear whether striatal ChI pathology is also associated with dystonia following neonatal brain injury. We used unbiased stereology to estimate striatal ChI and parvalbumin-positive GABAergic interneuron (PVI) numbers in a rodent model of neonatal brain injury that demonstrates electrophysiological markers of dystonia and spasticity. Striatal ChI numbers are increased following neonatal brain injury while PVI numbers are unchanged. These numbers do not correlate with electrophysiologic measures of dystonia severity. This suggests that striatal ChI pathology, though present, may not be the primary pathophysiologic contributor to dystonia following neonatal brain injury. Increased striatal ChI numbers could instead represent a passenger or protective phenomenon in the setting of dystonic CP.http://www.sciencedirect.com/science/article/pii/S096999612030320XNeonatal brain injuryCerebral palsyDystoniaSpasticity |
| spellingShingle | Sushma Gandham Yearam Tak Bhooma R. Aravamuthan Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy Neurobiology of Disease Neonatal brain injury Cerebral palsy Dystonia Spasticity |
| title | Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy |
| title_full | Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy |
| title_fullStr | Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy |
| title_full_unstemmed | Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy |
| title_short | Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy |
| title_sort | striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy |
| topic | Neonatal brain injury Cerebral palsy Dystonia Spasticity |
| url | http://www.sciencedirect.com/science/article/pii/S096999612030320X |
| work_keys_str_mv | AT sushmagandham striatalcholinergicinterneuronnumbersareincreasedinarodentmodelofdystoniccerebralpalsy AT yearamtak striatalcholinergicinterneuronnumbersareincreasedinarodentmodelofdystoniccerebralpalsy AT bhoomararavamuthan striatalcholinergicinterneuronnumbersareincreasedinarodentmodelofdystoniccerebralpalsy |