Effect of esophageal distention on basal and stimulated gastric acid secretion in rats
Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distenti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bushehr University of Medical Sciences
2007-02-01
|
| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-27&slc_lang=en&sid=1 |
| _version_ | 1818085297059004416 |
|---|---|
| author | Mohammad Kazem Gharib Nasery Seyed Ali Mard Mohammad Badvi |
| author_facet | Mohammad Kazem Gharib Nasery Seyed Ali Mard Mohammad Badvi |
| author_sort | Mohammad Kazem Gharib Nasery |
| collection | DOAJ |
| description | Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distention (ED) on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240g) were deprived of food but not water for 24 hrs before the experiments. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distention and gastric washout and the esophagus was cannulated with a distensible balloon orally to distend esophagus (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distention, carbachol (4 µg/kg, i.p.) or histamine (5 mg/kg, s.c.). Effects of vagotomy, L-NAME (10 mg/kg, i.v.), L-arginine (500 mg/kg, i.p.) and hexamethonium were also investigated. Results: Esophageal distention reduces basal and gastric distention, carbachol and histamine stimulated acid secretion (P<0.05, P<0.0001, P<0.01 and P<0.02, respectively). Vagotomy reduced the inhibitory effect of the esophagus distention on gastric distention-induced acid secretion (P<0.05). Conclusion: These results indicate that vagus nerve involves in the inhibitory effect of the esophageal distention on the basal and stimulated gastric acid secretion. Nitric oxide (NO) may also be involved. |
| first_indexed | 2024-12-10T20:07:32Z |
| format | Article |
| id | doaj.art-756c42fb31b24c4fb164a25037df6cdc |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-10T20:07:32Z |
| publishDate | 2007-02-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-756c42fb31b24c4fb164a25037df6cdc2022-12-22T01:35:22ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542007-02-0192114122Effect of esophageal distention on basal and stimulated gastric acid secretion in ratsMohammad Kazem Gharib Nasery0Seyed Ali Mard1Mohammad Badvi2 Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distention (ED) on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240g) were deprived of food but not water for 24 hrs before the experiments. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distention and gastric washout and the esophagus was cannulated with a distensible balloon orally to distend esophagus (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distention, carbachol (4 µg/kg, i.p.) or histamine (5 mg/kg, s.c.). Effects of vagotomy, L-NAME (10 mg/kg, i.v.), L-arginine (500 mg/kg, i.p.) and hexamethonium were also investigated. Results: Esophageal distention reduces basal and gastric distention, carbachol and histamine stimulated acid secretion (P<0.05, P<0.0001, P<0.01 and P<0.02, respectively). Vagotomy reduced the inhibitory effect of the esophagus distention on gastric distention-induced acid secretion (P<0.05). Conclusion: These results indicate that vagus nerve involves in the inhibitory effect of the esophageal distention on the basal and stimulated gastric acid secretion. Nitric oxide (NO) may also be involved.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-27&slc_lang=en&sid=1esophageal distention gastric acid secretion nitric oxide carbachol histamine vagotomy |
| spellingShingle | Mohammad Kazem Gharib Nasery Seyed Ali Mard Mohammad Badvi Effect of esophageal distention on basal and stimulated gastric acid secretion in rats Iranian South Medical Journal esophageal distention gastric acid secretion nitric oxide carbachol histamine vagotomy |
| title | Effect of esophageal distention on basal and stimulated gastric acid secretion in rats |
| title_full | Effect of esophageal distention on basal and stimulated gastric acid secretion in rats |
| title_fullStr | Effect of esophageal distention on basal and stimulated gastric acid secretion in rats |
| title_full_unstemmed | Effect of esophageal distention on basal and stimulated gastric acid secretion in rats |
| title_short | Effect of esophageal distention on basal and stimulated gastric acid secretion in rats |
| title_sort | effect of esophageal distention on basal and stimulated gastric acid secretion in rats |
| topic | esophageal distention gastric acid secretion nitric oxide carbachol histamine vagotomy |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-27&slc_lang=en&sid=1 |
| work_keys_str_mv | AT mohammadkazemgharibnasery effectofesophagealdistentiononbasalandstimulatedgastricacidsecretioninrats AT seyedalimard effectofesophagealdistentiononbasalandstimulatedgastricacidsecretioninrats AT mohammadbadvi effectofesophagealdistentiononbasalandstimulatedgastricacidsecretioninrats |