Parental vaccination to reduce measles immunity gaps in Italy
High-income countries are experiencing measles reemergence as the result of suboptimal vaccine uptake and marked immunity gaps among adults. In 2017, the Italian Government introduced mandatory vaccination at school entry for ten infectious diseases, including measles. However, sustainable and effec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/44942 |
| _version_ | 1818028461266042880 |
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| author | Valentina Marziano Piero Poletti Filippo Trentini Alessia Melegaro Marco Ajelli Stefano Merler |
| author_facet | Valentina Marziano Piero Poletti Filippo Trentini Alessia Melegaro Marco Ajelli Stefano Merler |
| author_sort | Valentina Marziano |
| collection | DOAJ |
| description | High-income countries are experiencing measles reemergence as the result of suboptimal vaccine uptake and marked immunity gaps among adults. In 2017, the Italian Government introduced mandatory vaccination at school entry for ten infectious diseases, including measles. However, sustainable and effective vaccination strategies targeting adults are still lacking. We use a data-driven model of household demography to estimate the potential impact on future measles epidemiology of a novel immunization strategy, to be implemented on top of the 2017 regulation, which consists of offering measles vaccine to the parents of children who get vaccinated. Model simulations suggest that the current vaccination efforts in Italy would not be sufficient to interrupt measles transmission before 2045 because of the frequency of susceptible individuals between 17 and 44 years of age. The integration of the current policy with parental vaccination has the potential to reduce susceptible adults by 17–35%, increasing the chance of measles elimination before 2045 up to 78.9–96.5%. |
| first_indexed | 2024-12-10T05:04:09Z |
| format | Article |
| id | doaj.art-756e055cd1304265859b10be1abb0ff1 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T05:04:09Z |
| publishDate | 2019-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-756e055cd1304265859b10be1abb0ff12022-12-22T02:01:18ZengeLife Sciences Publications LtdeLife2050-084X2019-09-01810.7554/eLife.44942Parental vaccination to reduce measles immunity gaps in ItalyValentina Marziano0https://orcid.org/0000-0003-2842-7906Piero Poletti1Filippo Trentini2Alessia Melegaro3https://orcid.org/0000-0003-2221-8898Marco Ajelli4Stefano Merler5Center for Information Technology, Fondazione Bruno Kessler, Trento, ItalyCenter for Information Technology, Fondazione Bruno Kessler, Trento, ItalyCenter for Information Technology, Fondazione Bruno Kessler, Trento, ItalyDepartment of Social and Political Sciences, Bocconi University, Milano, Italy; Carlo F Dondena Centre for Research on Social Dynamics and Public Policy, Bocconi University, Milano, ItalyCenter for Information Technology, Fondazione Bruno Kessler, Trento, Italy; Laboratory for the Modeling of Biological and Socio-Technical Systems, Northeastern University, Boston, United StatesCenter for Information Technology, Fondazione Bruno Kessler, Trento, ItalyHigh-income countries are experiencing measles reemergence as the result of suboptimal vaccine uptake and marked immunity gaps among adults. In 2017, the Italian Government introduced mandatory vaccination at school entry for ten infectious diseases, including measles. However, sustainable and effective vaccination strategies targeting adults are still lacking. We use a data-driven model of household demography to estimate the potential impact on future measles epidemiology of a novel immunization strategy, to be implemented on top of the 2017 regulation, which consists of offering measles vaccine to the parents of children who get vaccinated. Model simulations suggest that the current vaccination efforts in Italy would not be sufficient to interrupt measles transmission before 2045 because of the frequency of susceptible individuals between 17 and 44 years of age. The integration of the current policy with parental vaccination has the potential to reduce susceptible adults by 17–35%, increasing the chance of measles elimination before 2045 up to 78.9–96.5%.https://elifesciences.org/articles/44942measles eliminationschool entry vaccinationmandatory vaccinationparental vaccinationimmunity gapsmathematical model |
| spellingShingle | Valentina Marziano Piero Poletti Filippo Trentini Alessia Melegaro Marco Ajelli Stefano Merler Parental vaccination to reduce measles immunity gaps in Italy eLife measles elimination school entry vaccination mandatory vaccination parental vaccination immunity gaps mathematical model |
| title | Parental vaccination to reduce measles immunity gaps in Italy |
| title_full | Parental vaccination to reduce measles immunity gaps in Italy |
| title_fullStr | Parental vaccination to reduce measles immunity gaps in Italy |
| title_full_unstemmed | Parental vaccination to reduce measles immunity gaps in Italy |
| title_short | Parental vaccination to reduce measles immunity gaps in Italy |
| title_sort | parental vaccination to reduce measles immunity gaps in italy |
| topic | measles elimination school entry vaccination mandatory vaccination parental vaccination immunity gaps mathematical model |
| url | https://elifesciences.org/articles/44942 |
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