Ubiquitination events that regulate recombination of immunoglobulin loci gene segments
Programmed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity. Recombinase proteins RAG1 and RAG2, necessary for V...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00100/full |
| _version_ | 1818178444629901312 |
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| author | Jaime eChao Gerson eRothschild Uttiya eBasu |
| author_facet | Jaime eChao Gerson eRothschild Uttiya eBasu |
| author_sort | Jaime eChao |
| collection | DOAJ |
| description | Programmed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity. Recombinase proteins RAG1 and RAG2, necessary for V(D)J recombination, and Activation-Induced cytidine Deaminase (AID), an essential mutator protein for catalyzing class switch recombination (CSR) and somatic hypermutation (SHM), are regulated by various ubiquitination events that affect protein stability and activity. Programmed DNA breaks in the Ig loci can be identified by various components of DNA repair pathways, also regulated by protein ubiquitination. Errors in the ubiquitination pathways for any of the DNA double strand break repair proteins can lead to inefficient recombination and repair events, resulting in a compromised adaptive immune system or development of cancer. |
| first_indexed | 2024-12-11T20:48:05Z |
| format | Article |
| id | doaj.art-757138616eb54af6a008903e1fbd433b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T20:48:05Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-757138616eb54af6a008903e1fbd433b2022-12-22T00:51:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-03-01510.3389/fimmu.2014.0010079648Ubiquitination events that regulate recombination of immunoglobulin loci gene segmentsJaime eChao0Gerson eRothschild1Uttiya eBasu2Columbia UniversityColumbia UniversityColumbia UniversityProgrammed DNA mutagenesis events in the immunoglobulin (Ig) loci of developing B cells utilize the common and conserved mechanism of protein ubiquitination for subsequent proteasomal degradation to generate the required antigen-receptor diversity. Recombinase proteins RAG1 and RAG2, necessary for V(D)J recombination, and Activation-Induced cytidine Deaminase (AID), an essential mutator protein for catalyzing class switch recombination (CSR) and somatic hypermutation (SHM), are regulated by various ubiquitination events that affect protein stability and activity. Programmed DNA breaks in the Ig loci can be identified by various components of DNA repair pathways, also regulated by protein ubiquitination. Errors in the ubiquitination pathways for any of the DNA double strand break repair proteins can lead to inefficient recombination and repair events, resulting in a compromised adaptive immune system or development of cancer.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00100/fullDNA RepairUbiquitinationAIDClass switch recombinationsomatic hypermutationRAG proteins |
| spellingShingle | Jaime eChao Gerson eRothschild Uttiya eBasu Ubiquitination events that regulate recombination of immunoglobulin loci gene segments Frontiers in Immunology DNA Repair Ubiquitination AID Class switch recombination somatic hypermutation RAG proteins |
| title | Ubiquitination events that regulate recombination of immunoglobulin loci gene segments |
| title_full | Ubiquitination events that regulate recombination of immunoglobulin loci gene segments |
| title_fullStr | Ubiquitination events that regulate recombination of immunoglobulin loci gene segments |
| title_full_unstemmed | Ubiquitination events that regulate recombination of immunoglobulin loci gene segments |
| title_short | Ubiquitination events that regulate recombination of immunoglobulin loci gene segments |
| title_sort | ubiquitination events that regulate recombination of immunoglobulin loci gene segments |
| topic | DNA Repair Ubiquitination AID Class switch recombination somatic hypermutation RAG proteins |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00100/full |
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