Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer
Granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are cytokines of particular interest in oncology from the perspective of neutropenia management (Mehta et al., 2015 [1]) and also as indirect activators of tumor-associated macrophages and mod...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-04-01
|
| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917300562 |
| _version_ | 1818067165203398656 |
|---|---|
| author | Zachary A.P. Wintrob Jeffrey P. Hammel George K. Nimako Dan P. Gaile Alan Forrest Alice C. Ceacareanu |
| author_facet | Zachary A.P. Wintrob Jeffrey P. Hammel George K. Nimako Dan P. Gaile Alan Forrest Alice C. Ceacareanu |
| author_sort | Zachary A.P. Wintrob |
| collection | DOAJ |
| description | Granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are cytokines of particular interest in oncology from the perspective of neutropenia management (Mehta et al., 2015 [1]) and also as indirect activators of tumor-associated macrophages and modifiers of tumor microenvironment. Associated with poor breast cancer survival and unfavorable hormone receptor status (Wintrob et al., 2017 [2]), insulin may also influence hematopoiesis, thus interfering with colony stimulating factor production. Although G-CSF has been linked to exacerbating insulin resistance (Ordelheide et al., 2016 [3]), thus far no study linked insulin treatment and hematopoietic cytokines production. Additionally, IL-7 is the primary driver of T and B cell differentiation, maturation, and response (Corfe and Paige, 2012 [4]) and its elevated levels have been associated with poor prognosis in breast cancer.
The data presented here is among the first to show a relationship between pre-existing use of injectable insulin in women diagnosed with breast cancer and type 2 diabetes mellitus, hematopoietic cytokine profiles at time of breast cancer diagnosis, and subsequent cancer outcomes. A Pearson correlation analysis evaluating the relationship between G-CSF, GM-CSF, and IL-7 stratified by insulin use, controls, as well as by estrogen and progesterone receptor status is also provided. |
| first_indexed | 2024-12-10T15:19:20Z |
| format | Article |
| id | doaj.art-757402dea7d148e6a6a2ce6c38d9a4ef |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-10T15:19:20Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-757402dea7d148e6a6a2ce6c38d9a4ef2022-12-22T01:43:43ZengElsevierData in Brief2352-34092017-04-0111C38239010.1016/j.dib.2017.02.037Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancerZachary A.P. Wintrob0Jeffrey P. Hammel1George K. Nimako2Dan P. Gaile3Alan Forrest4Alice C. Ceacareanu5State University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, USACleveland Clinic, Dept. of Biostatistics and Epidemiology, 9500 Euclid Ave., Cleveland, OH 44195, USAState University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, USAState University of New York at Buffalo, Dept. of Biostatistics, 718 Kimball Tower, Buffalo, NY 14214, USAThe UNC Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, Campus Box 7569, Chapel Hill, NC 27599, USAState University of New York at Buffalo, Dept. of Pharmacy Practice, NYS Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, USAGranulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) are cytokines of particular interest in oncology from the perspective of neutropenia management (Mehta et al., 2015 [1]) and also as indirect activators of tumor-associated macrophages and modifiers of tumor microenvironment. Associated with poor breast cancer survival and unfavorable hormone receptor status (Wintrob et al., 2017 [2]), insulin may also influence hematopoiesis, thus interfering with colony stimulating factor production. Although G-CSF has been linked to exacerbating insulin resistance (Ordelheide et al., 2016 [3]), thus far no study linked insulin treatment and hematopoietic cytokines production. Additionally, IL-7 is the primary driver of T and B cell differentiation, maturation, and response (Corfe and Paige, 2012 [4]) and its elevated levels have been associated with poor prognosis in breast cancer. The data presented here is among the first to show a relationship between pre-existing use of injectable insulin in women diagnosed with breast cancer and type 2 diabetes mellitus, hematopoietic cytokine profiles at time of breast cancer diagnosis, and subsequent cancer outcomes. A Pearson correlation analysis evaluating the relationship between G-CSF, GM-CSF, and IL-7 stratified by insulin use, controls, as well as by estrogen and progesterone receptor status is also provided.http://www.sciencedirect.com/science/article/pii/S2352340917300562HematopoiesisHematopoietic cytokinesG-CSFGM-CSFIL-7InsulinBreast cancerDiabetesCancer outcomesCancer prognosisEstrogen receptorProgesterone receptorERPR |
| spellingShingle | Zachary A.P. Wintrob Jeffrey P. Hammel George K. Nimako Dan P. Gaile Alan Forrest Alice C. Ceacareanu Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer Data in Brief Hematopoiesis Hematopoietic cytokines G-CSF GM-CSF IL-7 Insulin Breast cancer Diabetes Cancer outcomes Cancer prognosis Estrogen receptor Progesterone receptor ER PR |
| title | Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer |
| title_full | Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer |
| title_fullStr | Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer |
| title_full_unstemmed | Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer |
| title_short | Insulin use, hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer |
| title_sort | insulin use hormone receptor status and hematopoietic cytokines׳ circulation in women with diabetes mellitus and breast cancer |
| topic | Hematopoiesis Hematopoietic cytokines G-CSF GM-CSF IL-7 Insulin Breast cancer Diabetes Cancer outcomes Cancer prognosis Estrogen receptor Progesterone receptor ER PR |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917300562 |
| work_keys_str_mv | AT zacharyapwintrob insulinusehormonereceptorstatusandhematopoieticcytokinescirculationinwomenwithdiabetesmellitusandbreastcancer AT jeffreyphammel insulinusehormonereceptorstatusandhematopoieticcytokinescirculationinwomenwithdiabetesmellitusandbreastcancer AT georgeknimako insulinusehormonereceptorstatusandhematopoieticcytokinescirculationinwomenwithdiabetesmellitusandbreastcancer AT danpgaile insulinusehormonereceptorstatusandhematopoieticcytokinescirculationinwomenwithdiabetesmellitusandbreastcancer AT alanforrest insulinusehormonereceptorstatusandhematopoieticcytokinescirculationinwomenwithdiabetesmellitusandbreastcancer AT alicecceacareanu insulinusehormonereceptorstatusandhematopoieticcytokinescirculationinwomenwithdiabetesmellitusandbreastcancer |