Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis
Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with nonredundant functions are encoded by a set of host genes, the res...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-10-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/1/3/460/ |
| _version_ | 1823985575907033088 |
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| author | Philippe Georgel Karine Crozat |
| author_facet | Philippe Georgel Karine Crozat |
| author_sort | Philippe Georgel |
| collection | DOAJ |
| description | Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with nonredundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagenized mice for susceptibility to a natural opportunistic pathogen, the mouse cytomegalovirus. We found that some genes with initially no obvious functions in innate immunity may be critical for host survival to infections, falling into a newly defined category of genes of the resistome. |
| first_indexed | 2024-12-18T12:56:52Z |
| format | Article |
| id | doaj.art-757405f79e4c45c9ada33293f016e3ac |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-18T12:56:52Z |
| publishDate | 2009-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-757405f79e4c45c9ada33293f016e3ac2022-12-21T21:07:17ZengMDPI AGViruses1999-49152009-10-011346048310.3390/v1030460Identification of Mouse Cytomegalovirus Resistance Loci by ENU MutagenesisPhilippe GeorgelKarine CrozatHost resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with nonredundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagenized mice for susceptibility to a natural opportunistic pathogen, the mouse cytomegalovirus. We found that some genes with initially no obvious functions in innate immunity may be critical for host survival to infections, falling into a newly defined category of genes of the resistome.http://www.mdpi.com/1999-4915/1/3/460/N-ethyl-N-nitrosoureamutagenesisresistomemouse cytomegalovirussusceptibilityinnate immunityhomeostasis |
| spellingShingle | Philippe Georgel Karine Crozat Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis Viruses N-ethyl-N-nitrosourea mutagenesis resistome mouse cytomegalovirus susceptibility innate immunity homeostasis |
| title | Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis |
| title_full | Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis |
| title_fullStr | Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis |
| title_full_unstemmed | Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis |
| title_short | Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis |
| title_sort | identification of mouse cytomegalovirus resistance loci by enu mutagenesis |
| topic | N-ethyl-N-nitrosourea mutagenesis resistome mouse cytomegalovirus susceptibility innate immunity homeostasis |
| url | http://www.mdpi.com/1999-4915/1/3/460/ |
| work_keys_str_mv | AT philippegeorgel identificationofmousecytomegalovirusresistancelocibyenumutagenesis AT karinecrozat identificationofmousecytomegalovirusresistancelocibyenumutagenesis |