Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles
Supramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles (CP5@Au-NPs) as receptor and...
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| Format: | Article |
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MDPI AG
2018-11-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/18/11/3927 |
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| author | Xiaoping Tan Yang Yang Shasha Luo Zhong Zhang Wenjie Zeng Tingying Zhang Fawu Su Linzong Zhou |
| author_facet | Xiaoping Tan Yang Yang Shasha Luo Zhong Zhang Wenjie Zeng Tingying Zhang Fawu Su Linzong Zhou |
| author_sort | Xiaoping Tan |
| collection | DOAJ |
| description | Supramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles (CP5@Au-NPs) as receptor and probe (rhodamine 123, R123), which shown high sensitivity and selectivity for L-carnitine detection. Due to the negative charge and molecular size properties of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The host-guest mechanism between PP5 and L-carnitine was studied by <sup>1</sup>H NMR and molecular docking, indicating that more affinity binding force of CP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1⁻2.0 and 2.0⁻25.0 μM and a detection limit of 0.067 μM (S/N = 3). The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications for the detection of drugs abuse and had path for guarding a serious food safety issues. |
| first_indexed | 2024-04-11T11:07:31Z |
| format | Article |
| id | doaj.art-7575eed50d9d4920b38e17eaf05d2d16 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T11:07:31Z |
| publishDate | 2018-11-01 |
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| spelling | doaj.art-7575eed50d9d4920b38e17eaf05d2d162022-12-22T04:28:16ZengMDPI AGSensors1424-82202018-11-011811392710.3390/s18113927s18113927Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold NanoparticlesXiaoping Tan0Yang Yang1Shasha Luo2Zhong Zhang3Wenjie Zeng4Tingying Zhang5Fawu Su6Linzong Zhou7Key Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, ChinaKey Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, ChinaKey Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, ChinaKey Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, ChinaKey Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, ChinaKey Lab of Inorganic Special Functional Materials, Chongqing Municipal Education Commission, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100, ChinaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650224, ChinaSchool of Geographical Science and Tourism Management, Chuxiong Normal University, Chuxiong 675000, ChinaSupramolecular host-guest interaction and sensing between cationic pillar[5]arenes (CP5) and L-carnitine were developed by the competitive host-guest recognition for the first time. The fluorescence sensing platform was constructed by CP5 functionalized Au nanoparticles (CP5@Au-NPs) as receptor and probe (rhodamine 123, R123), which shown high sensitivity and selectivity for L-carnitine detection. Due to the negative charge and molecular size properties of L-carnitine, it can be highly captured by the CP5 via electrostatic interactions and hydrophobic interactions. The host-guest mechanism between PP5 and L-carnitine was studied by <sup>1</sup>H NMR and molecular docking, indicating that more affinity binding force of CP5 with L-carnitine. Therefore, a selective and sensitive fluorescent method was developed. It has a linear response of 0.1⁻2.0 and 2.0⁻25.0 μM and a detection limit of 0.067 μM (S/N = 3). The fluorescent sensing platform was also used to detect L-carnitine in human serum and milk samples, which provided potential applications for the detection of drugs abuse and had path for guarding a serious food safety issues.https://www.mdpi.com/1424-8220/18/11/3927cationic pillar[5]areneshost–guest recognitionAu nanoparticlesL-carnitine |
| spellingShingle | Xiaoping Tan Yang Yang Shasha Luo Zhong Zhang Wenjie Zeng Tingying Zhang Fawu Su Linzong Zhou Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles Sensors cationic pillar[5]arenes host–guest recognition Au nanoparticles L-carnitine |
| title | Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles |
| title_full | Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles |
| title_fullStr | Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles |
| title_full_unstemmed | Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles |
| title_short | Novel Competitive Fluorescence Sensing Platform for L-carnitine Based on Cationic Pillar[5]Arene Modified Gold Nanoparticles |
| title_sort | novel competitive fluorescence sensing platform for l carnitine based on cationic pillar 5 arene modified gold nanoparticles |
| topic | cationic pillar[5]arenes host–guest recognition Au nanoparticles L-carnitine |
| url | https://www.mdpi.com/1424-8220/18/11/3927 |
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