Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

Abstract Background High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a Damage-Associated Molecular Pattern molecule when released from necrotic cells or activated leukocytes. HMGB1 consists of two struc...

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Bibliographic Details
Main Authors: Mingzhu He, Marco E. Bianchi, Tom R. Coleman, Kevin J. Tracey, Yousef Al-Abed
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Medicine
Subjects:
HMGB1
TLR4/MD-2 complex
Surface plasmon resonance (SPR)
Antagonist
TLR4-signaling
Online Access:http://link.springer.com/article/10.1186/s10020-018-0023-8

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