Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease
BackgroundOne measurement of hs‐CRP (high‐sensitivity C‐reactive protein) is associated with increased risk of cardiovascular disease (CVD). The objective of this study was to characterize the association of cumulative exposure to increased hs‐CRP with incident cardiovascular events. Methods and Res...
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| Format: | Article |
| Language: | English |
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Wiley
2017-10-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.005610 |
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| author | Aitian Wang Jie Liu Chunguang Li Jingli Gao Xiaolan Li Shuohua Chen Shouling Wu Hui Ding Haojun Fan Shike Hou |
| author_facet | Aitian Wang Jie Liu Chunguang Li Jingli Gao Xiaolan Li Shuohua Chen Shouling Wu Hui Ding Haojun Fan Shike Hou |
| author_sort | Aitian Wang |
| collection | DOAJ |
| description | BackgroundOne measurement of hs‐CRP (high‐sensitivity C‐reactive protein) is associated with increased risk of cardiovascular disease (CVD). The objective of this study was to characterize the association of cumulative exposure to increased hs‐CRP with incident cardiovascular events. Methods and ResultsWe included 53 065 participants with hs‐CRP measured at 3 examinations in 2006, 2008, and 2010. Cumulative exposure to hs‐CRP was calculated as the weighted sum of the average hs‐CRP level for each time interval (level×time). Participants were classified into nonexposed group (hs‐CRP<3.0 mg/L in all 3 examinations), 1‐exposed group (hs‐CRP≥3.0 mg/L in 1 of the 3 examinations), 2‐exposed group (hs‐CRP≥3.0 mg/L in 2 of the 3 examinations), and 3‐exposed group (hs‐CRP≥3.0 mg/L in 3 examinations). Cox proportional hazards models were used to assess the association of cumulative hs‐CRP with incident CVD. The study showed a dose‐response pattern with risk of CVD and myocardial infarction as the number of years of exposure to hs‐CRP increases. Participants in the 3‐exposed group had significantly increased CVD risk with hazard ratio (95% confidence interval) of 1.38 (1.11–1.72), in comparison with 1.28 (1.07–1.52) for participants in the 2‐exposed group and 1.13 (0.97–1.31) for those in the 1‐exposed group (P<0.05); meanwhile, the similar and significant associations were also observed for myocardial infarction with respective hazard ratio (95% confidence interval) of 2.13 (1.42–3.18), 1.60 (1.12–2.27), and 1.57 (1.17–2.10). The associations between stroke and cumulative hs‐CRP were not statistically significant (P=0.360). ConclusionsCumulative exposure to hs‐CRP was dose dependently associated with a subsequent increased risk of CVD and myocardial infarction. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov/. Unique identifier: ChiCTR‐TNC‐11001489. |
| first_indexed | 2024-04-13T16:40:01Z |
| format | Article |
| id | doaj.art-75794b1410e84af4a623b597f6fa7c4d |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:40:01Z |
| publishDate | 2017-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-75794b1410e84af4a623b597f6fa7c4d2022-12-22T02:39:16ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-10-0161010.1161/JAHA.117.005610Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular DiseaseAitian Wang0Jie Liu1Chunguang Li2Jingli Gao3Xiaolan Li4Shuohua Chen5Shouling Wu6Hui Ding7Haojun Fan8Shike Hou9Tianjin Medical University, Tianjin, ChinaDepartment of Cardiology, Affiliated Hospital of North China University of Science and Technology, Tangshan, ChinaDepartment of Cardiology, Tangshan Workers’ Hospital, Tangshan, ChinaDepartment of Intensive medicine, Kailuan General Hospital, Tangshan, ChinaDepartment of Intensive medicine, Kailuan General Hospital, Tangshan, ChinaDepartment of Cardiology, Kailuan General Hospital, Tangshan, ChinaDepartment of Cardiology, Kailuan General Hospital, Tangshan, ChinaKey Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces, Tianjin, ChinaKey Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces, Tianjin, ChinaKey Laboratory of Emergency and Disaster Medicine in Chinese People's Liberation Army, Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistics University of Chinese People's Army Police Forces, Tianjin, ChinaBackgroundOne measurement of hs‐CRP (high‐sensitivity C‐reactive protein) is associated with increased risk of cardiovascular disease (CVD). The objective of this study was to characterize the association of cumulative exposure to increased hs‐CRP with incident cardiovascular events. Methods and ResultsWe included 53 065 participants with hs‐CRP measured at 3 examinations in 2006, 2008, and 2010. Cumulative exposure to hs‐CRP was calculated as the weighted sum of the average hs‐CRP level for each time interval (level×time). Participants were classified into nonexposed group (hs‐CRP<3.0 mg/L in all 3 examinations), 1‐exposed group (hs‐CRP≥3.0 mg/L in 1 of the 3 examinations), 2‐exposed group (hs‐CRP≥3.0 mg/L in 2 of the 3 examinations), and 3‐exposed group (hs‐CRP≥3.0 mg/L in 3 examinations). Cox proportional hazards models were used to assess the association of cumulative hs‐CRP with incident CVD. The study showed a dose‐response pattern with risk of CVD and myocardial infarction as the number of years of exposure to hs‐CRP increases. Participants in the 3‐exposed group had significantly increased CVD risk with hazard ratio (95% confidence interval) of 1.38 (1.11–1.72), in comparison with 1.28 (1.07–1.52) for participants in the 2‐exposed group and 1.13 (0.97–1.31) for those in the 1‐exposed group (P<0.05); meanwhile, the similar and significant associations were also observed for myocardial infarction with respective hazard ratio (95% confidence interval) of 2.13 (1.42–3.18), 1.60 (1.12–2.27), and 1.57 (1.17–2.10). The associations between stroke and cumulative hs‐CRP were not statistically significant (P=0.360). ConclusionsCumulative exposure to hs‐CRP was dose dependently associated with a subsequent increased risk of CVD and myocardial infarction. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov/. Unique identifier: ChiCTR‐TNC‐11001489.https://www.ahajournals.org/doi/10.1161/JAHA.117.005610cardiovascular diseasecohort studyhigh sensitivity C‐reactive proteinincidencerisk factor |
| spellingShingle | Aitian Wang Jie Liu Chunguang Li Jingli Gao Xiaolan Li Shuohua Chen Shouling Wu Hui Ding Haojun Fan Shike Hou Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular disease cohort study high sensitivity C‐reactive protein incidence risk factor |
| title | Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease |
| title_full | Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease |
| title_fullStr | Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease |
| title_full_unstemmed | Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease |
| title_short | Cumulative Exposure to High‐Sensitivity C‐Reactive Protein Predicts the Risk of Cardiovascular Disease |
| title_sort | cumulative exposure to high sensitivity c reactive protein predicts the risk of cardiovascular disease |
| topic | cardiovascular disease cohort study high sensitivity C‐reactive protein incidence risk factor |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.005610 |
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