THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
The production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This...
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2013-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/1589 |
| _version_ | 1797237486260322304 |
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| author | O. A. Dyakovich |
| author_facet | O. A. Dyakovich |
| author_sort | O. A. Dyakovich |
| collection | DOAJ |
| description | The production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This article provides a brief review of the literature on the role of bio transformation system in functional disorders of the liver in PVC production workers. We describe the first and second phases of the biotransformation of lipophilic xenobiotics in the human body, for example, vinyl chloride. The data on gene polymorphism of enzymes involved in the metabolism of vinyl chloride (isoform of cytochrome P450 - CYP2E1, glutathione transferase GSTM1 and GSTT1) were presented in this article. The results of experimental studies of the effect of vinyl chloride on the state of the biotransformation of xenobiotics were reflected. This article examined the factors affecting the activity of the system in terms of the production of vinyl chloride exposure - age, smoking and alcohol. |
| first_indexed | 2024-03-08T12:20:56Z |
| format | Article |
| id | doaj.art-7579a91f866a4a429d34049499f3cb9c |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:20:31Z |
| publishDate | 2013-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-7579a91f866a4a429d34049499f3cb9c2024-03-28T07:49:11ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-05-0103(1)1641681535THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDEO. A. Dyakovich0Eastern-Siberian Scientific Center of Human EcologyThe production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This article provides a brief review of the literature on the role of bio transformation system in functional disorders of the liver in PVC production workers. We describe the first and second phases of the biotransformation of lipophilic xenobiotics in the human body, for example, vinyl chloride. The data on gene polymorphism of enzymes involved in the metabolism of vinyl chloride (isoform of cytochrome P450 - CYP2E1, glutathione transferase GSTM1 and GSTT1) were presented in this article. The results of experimental studies of the effect of vinyl chloride on the state of the biotransformation of xenobiotics were reflected. This article examined the factors affecting the activity of the system in terms of the production of vinyl chloride exposure - age, smoking and alcohol.https://www.actabiomedica.ru/jour/article/view/1589vinyl chloridemetabolites of vinyl chloridexenobiotics biotransformationmodifying factorsgene polymorphism |
| spellingShingle | O. A. Dyakovich THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE Acta Biomedica Scientifica vinyl chloride metabolites of vinyl chloride xenobiotics biotransformation modifying factors gene polymorphism |
| title | THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE |
| title_full | THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE |
| title_fullStr | THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE |
| title_full_unstemmed | THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE |
| title_short | THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE |
| title_sort | role of xenobiotic biotransformation in the development of liver diseases in occupational exposure to vinyl chloride |
| topic | vinyl chloride metabolites of vinyl chloride xenobiotics biotransformation modifying factors gene polymorphism |
| url | https://www.actabiomedica.ru/jour/article/view/1589 |
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