Expansion With IL-15 Increases Cytotoxicity of Vγ9Vδ2 T Cells and Is Associated With Higher Levels of Cytotoxic Molecules and T-bet

Expansion With IL-15 Increases Cytotoxicity of Vγ9Vδ2 T Cells and Is Associated With Higher Levels of Cytotoxic Molecules and T-bet

Cancer immunotherapy has shown great advances during recent years, but it has yet to reach its full potential in all cancer types. Adoptive cell therapy (ACT) is now an approved treatment option for certain hematological cancers and has also shown success for some solid cancers. Still, benefit and e...

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Bibliographic Details
Main Authors: Pia Aehnlich, Ana Micaela Carnaz Simões, Signe Koggersbøl Skadborg, Gitte Holmen Olofsson, Per thor Straten
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
Vγ9Vδ2 T cells
gamma delta T cells
adoptive cell therapy
IL-15
IL15
cytotoxicity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01868/full

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