Lichen planus flare following COVID‐19 vaccination: A case report

Lichen planus flare following COVID‐19 vaccination: A case report

Abstract We report the third case of cutaneous lichen planus (LP) following COVID‐19 BNT162b2 vaccination in a 59‐year‐old woman with previous LP. The reactivation of LP in patients with dormant LP suggests a possible vaccine‐induced immune dysregulation. We suggest that the already described vaccin...

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Bibliographic Details
Main Authors: Astrid Herzum, Martina Burlando, Mattia F. Molle, Claudia Micalizzi, Emanuele Cozzani, Aurora Parodi
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Clinical Case Reports
Subjects:
COVID‐19 cutaneous
COVID‐19 skin
COVID‐19 vaccination
COVID‐19 vaccine
lichen planus
Online Access:https://doi.org/10.1002/ccr3.5092
Description
Summary:Abstract We report the third case of cutaneous lichen planus (LP) following COVID‐19 BNT162b2 vaccination in a 59‐year‐old woman with previous LP. The reactivation of LP in patients with dormant LP suggests a possible vaccine‐induced immune dysregulation. We suggest that the already described vaccine‐induced upregulation of Th1 response may play a relevant role in LP reactivation, through an increase in inflammatory cytokines involved in the pathogenesis of LP. Interestingly, LP has already been associated with vaccinations and viral infections including COVID‐19 disease. However, the exact mechanism underlying LP (re)activation after Pfizer‐BiotNtech COVID‐19 vaccination is still widely unknown and needs to be further investigated.
ISSN:2050-0904

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