Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells

Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells

Reprogramming of energy metabolism is regarded as one of the hallmarks of cancer; in particular, oncogenic RAS has been shown to be a critical regulator of cancer metabolism. Recently, asparagine metabolism has been heavily investigated as a novel target for cancer treatment. For example, Knott et a...

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Bibliographic Details
Main Authors: Gen Nishikawa, Kenji Kawada, Keita Hanada, Hisatsugu Maekawa, Yoshiro Itatani, Hiroyuki Miyoshi, Makoto Mark Taketo, Kazutaka Obama
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
asparagine synthetase
asparagine metabolism
L-asparaginase
KRAS-driven cancer
patient-derived spheroid
patient-derived spheroid xenograft
Online Access:https://www.mdpi.com/2073-4409/11/20/3273

Internet

https://www.mdpi.com/2073-4409/11/20/3273

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