The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin
Abstract Background This study aims to explore the antibacterial activity of cethromycin against Staphylococcus aureus (S. aureus), and its relationship with multilocus sequence typing (MLST), erythromycin ribosomal methylase (erm) genes and macrolide-lincosamide-streptogramin B (MLSB) phenotypes of...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Microbiology |
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| Online Access: | https://doi.org/10.1186/s12866-023-02858-1 |
| _version_ | 1827961414389596160 |
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| author | Yuechen Hu Lili Ouyang Duoyun Li Xiangbin Deng Hongbo Xu Zhijian Yu Yeqing Fang Jinxin Zheng Zhong Chen Haigang Zhang |
| author_facet | Yuechen Hu Lili Ouyang Duoyun Li Xiangbin Deng Hongbo Xu Zhijian Yu Yeqing Fang Jinxin Zheng Zhong Chen Haigang Zhang |
| author_sort | Yuechen Hu |
| collection | DOAJ |
| description | Abstract Background This study aims to explore the antibacterial activity of cethromycin against Staphylococcus aureus (S. aureus), and its relationship with multilocus sequence typing (MLST), erythromycin ribosomal methylase (erm) genes and macrolide-lincosamide-streptogramin B (MLSB) phenotypes of S. aureus. Results The minimum inhibitory concentrations (MICs) of cethromycin against 245 S. aureus clinical isolates ranged from 0.03125 to ≥ 8 mg/L, with the resistance of 38.8% in 121 methicillin-resistant S. aureus (MRSA). This study also found that cethromycin had strong antibacterial activity against S. aureus, with the MIC ≤ 0.5 mg/L in 55.4% of MRSA and 60.5% of methicillin-sensitive S. aureus (MSSA), respectively. The main MLSTs of 121 MRSA were ST239 and ST59, and the resistance of ST239 isolates to cethromycin was higher than that in ST59 isolates (P = 0.034). The top five MLSTs of 124 MSSA were ST7, ST59, ST398, ST88 and ST120, but there was no difference in the resistance of MSSA to cethromycin between these STs. The resistance of ermA isolates to cethromycin was higher than that of ermB or ermC isolates in MRSA (P = 0.016 and 0.041, respectively), but the resistance of ermB or ermC isolates to cethromycin was higher than that of ermA isolates in MSSA (P = 0.019 and 0.026, respectively). The resistance of constitutive MLSB (cMLSB) phenotype isolates to cethromycin was higher than that of inducible MLSB (iMLSB) phenotype isolates in MRSA (P < 0.001) or MSSA (P = 0.036). The ermA, ermB and ermC genes was mainly found in ST239, ST59 and ST1 isolates in MRSA, respectively. Among the MSSA, the ermC gene was more detected in ST7, ST88 and ST120 isolates, but more ermB genes were detected in ST59 and ST398 isolates. The cMLSB phenotype was more common in ST239 and ST59 isolates of MRSA, and was more frequently detected in ST59, ST398, and ST120 isolates of MSSA. Conclusion Cethromycin had strong antibacterial activity against S. aureus. The resistance of MRSA to cethromycin may had some clonal aggregation in ST239. The resistance of S. aureus carrying various erm genes or MLSB phenotypes to cethromycin was different. |
| first_indexed | 2024-04-09T16:26:25Z |
| format | Article |
| id | doaj.art-757e04967652424fb57502b0a88c8b8c |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-04-09T16:26:25Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
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| series | BMC Microbiology |
| spelling | doaj.art-757e04967652424fb57502b0a88c8b8c2023-04-23T11:10:56ZengBMCBMC Microbiology1471-21802023-04-0123111010.1186/s12866-023-02858-1The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycinYuechen Hu0Lili Ouyang1Duoyun Li2Xiangbin Deng3Hongbo Xu4Zhijian Yu5Yeqing Fang6Jinxin Zheng7Zhong Chen8Haigang Zhang9Department of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Critical Care Medicine and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Cardiology, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Infectious Diseases and Shenzhen Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterDepartment of Critical Care Medicine and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s Hospital and the 6Th Affiliated Hospital of Shenzhen University Health Science CenterAbstract Background This study aims to explore the antibacterial activity of cethromycin against Staphylococcus aureus (S. aureus), and its relationship with multilocus sequence typing (MLST), erythromycin ribosomal methylase (erm) genes and macrolide-lincosamide-streptogramin B (MLSB) phenotypes of S. aureus. Results The minimum inhibitory concentrations (MICs) of cethromycin against 245 S. aureus clinical isolates ranged from 0.03125 to ≥ 8 mg/L, with the resistance of 38.8% in 121 methicillin-resistant S. aureus (MRSA). This study also found that cethromycin had strong antibacterial activity against S. aureus, with the MIC ≤ 0.5 mg/L in 55.4% of MRSA and 60.5% of methicillin-sensitive S. aureus (MSSA), respectively. The main MLSTs of 121 MRSA were ST239 and ST59, and the resistance of ST239 isolates to cethromycin was higher than that in ST59 isolates (P = 0.034). The top five MLSTs of 124 MSSA were ST7, ST59, ST398, ST88 and ST120, but there was no difference in the resistance of MSSA to cethromycin between these STs. The resistance of ermA isolates to cethromycin was higher than that of ermB or ermC isolates in MRSA (P = 0.016 and 0.041, respectively), but the resistance of ermB or ermC isolates to cethromycin was higher than that of ermA isolates in MSSA (P = 0.019 and 0.026, respectively). The resistance of constitutive MLSB (cMLSB) phenotype isolates to cethromycin was higher than that of inducible MLSB (iMLSB) phenotype isolates in MRSA (P < 0.001) or MSSA (P = 0.036). The ermA, ermB and ermC genes was mainly found in ST239, ST59 and ST1 isolates in MRSA, respectively. Among the MSSA, the ermC gene was more detected in ST7, ST88 and ST120 isolates, but more ermB genes were detected in ST59 and ST398 isolates. The cMLSB phenotype was more common in ST239 and ST59 isolates of MRSA, and was more frequently detected in ST59, ST398, and ST120 isolates of MSSA. Conclusion Cethromycin had strong antibacterial activity against S. aureus. The resistance of MRSA to cethromycin may had some clonal aggregation in ST239. The resistance of S. aureus carrying various erm genes or MLSB phenotypes to cethromycin was different.https://doi.org/10.1186/s12866-023-02858-1Staphylococcus aureusCethromycinMultilocus sequence typingErmMacrolide-lincosamide-streptogramin B |
| spellingShingle | Yuechen Hu Lili Ouyang Duoyun Li Xiangbin Deng Hongbo Xu Zhijian Yu Yeqing Fang Jinxin Zheng Zhong Chen Haigang Zhang The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin BMC Microbiology Staphylococcus aureus Cethromycin Multilocus sequence typing Erm Macrolide-lincosamide-streptogramin B |
| title | The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin |
| title_full | The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin |
| title_fullStr | The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin |
| title_full_unstemmed | The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin |
| title_short | The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin |
| title_sort | antimicrobial activity of cethromycin against staphylococcus aureus and compared with erythromycin and telithromycin |
| topic | Staphylococcus aureus Cethromycin Multilocus sequence typing Erm Macrolide-lincosamide-streptogramin B |
| url | https://doi.org/10.1186/s12866-023-02858-1 |
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