Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects
Objective: Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013. Methods: Cross‐sectional study i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2015-07-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553615000580 |
| _version_ | 1797984485575229440 |
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| author | Rosângela S.L.A. Torres Talita Z. Santos Robson A.A. Torres Valéria V.G. Pereira Lucas A.F. Fávero Otavio R.M. Filho Margareth L. Penkal Leni S. Araujo |
| author_facet | Rosângela S.L.A. Torres Talita Z. Santos Robson A.A. Torres Valéria V.G. Pereira Lucas A.F. Fávero Otavio R.M. Filho Margareth L. Penkal Leni S. Araujo |
| author_sort | Rosângela S.L.A. Torres |
| collection | DOAJ |
| description | Objective: Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013.
Methods: Cross‐sectional study including 1,209 patients with pertussis. Data were obtained through the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação – SINAN) and molecular epidemiology was performed by repetitive sequence‐based polymerase chain reaction (rep‐PCR; DiversiLab®, bioMerieux, France).
Results: The incidence of pertussis in the state of Paraná increased sharply from 0.15‐0.76 per 100,000 habitants between 2007‐2010 to 1.7‐4.28 per 100,000 between 2011‐2013. Patients with less than 1 year of age were more stricken (67.5%). Fifty‐nine children (5%) developed pertussis even after receiving three doses and two diphtheria‐tetanus‐pertussis (DTP) boosters vaccine. The most common complications were pneumonia (14.5%), otitis (0.9%), and encephalopathy (0.7%). Isolates of B. pertussis were grouped into two groups (G1 and G2) and eight distinct patterns (G1: P1‐P5 and G2: P6‐P8).
Conclusion: The resurgence of pertussis should stimulate new research to develop vaccines with greater capacity of protection against current clones and also encourage implementation of new strategies for vaccination in order to reduce the risk of disease in infants. |
| first_indexed | 2024-04-11T07:03:28Z |
| format | Article |
| id | doaj.art-757f377b3b5f46e99a8bd86e3d5fcce9 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-11T07:03:28Z |
| publishDate | 2015-07-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-757f377b3b5f46e99a8bd86e3d5fcce92022-12-22T04:38:34ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362015-07-0191433333810.1016/j.jpedp.2015.04.006Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspectsRosângela S.L.A. Torres0Talita Z. Santos1Robson A.A. Torres2Valéria V.G. Pereira3Lucas A.F. Fávero4Otavio R.M. Filho5Margareth L. Penkal6Leni S. Araujo7Laboratório de Bacteriologia, Divisão de Laboratórios de Epidemiologia e Controle de Doenças, Laboratório Central do Estado do Paraná, Curitiba, PR, BrasilPontifícia Universidade Católica do Paraná (PUC‐PR), Curitiba, PR, BrasilUniversidade Positivo, Curitiba, PR, BrasilLaboratório de Bacteriologia, Divisão de Laboratórios de Epidemiologia e Controle de Doenças, Laboratório Central do Estado do Paraná, Curitiba, PR, BrasilUniversidade Positivo, Curitiba, PR, BrasilUniversidade Positivo, Curitiba, PR, BrasilLaboratório de Bacteriologia, Divisão de Laboratórios de Epidemiologia e Controle de Doenças, Laboratório Central do Estado do Paraná, Curitiba, PR, BrasilDivisão de Vigilância das Doenças Transmissíveis, Centro de Epidemiologia, Secretaria da Saúde do Paraná, Curitiba, PR, BrasilObjective: Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013. Methods: Cross‐sectional study including 1,209 patients with pertussis. Data were obtained through the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação – SINAN) and molecular epidemiology was performed by repetitive sequence‐based polymerase chain reaction (rep‐PCR; DiversiLab®, bioMerieux, France). Results: The incidence of pertussis in the state of Paraná increased sharply from 0.15‐0.76 per 100,000 habitants between 2007‐2010 to 1.7‐4.28 per 100,000 between 2011‐2013. Patients with less than 1 year of age were more stricken (67.5%). Fifty‐nine children (5%) developed pertussis even after receiving three doses and two diphtheria‐tetanus‐pertussis (DTP) boosters vaccine. The most common complications were pneumonia (14.5%), otitis (0.9%), and encephalopathy (0.7%). Isolates of B. pertussis were grouped into two groups (G1 and G2) and eight distinct patterns (G1: P1‐P5 and G2: P6‐P8). Conclusion: The resurgence of pertussis should stimulate new research to develop vaccines with greater capacity of protection against current clones and also encourage implementation of new strategies for vaccination in order to reduce the risk of disease in infants.http://www.sciencedirect.com/science/article/pii/S2255553615000580Whooping coughClonesBordetella pertussisRep‐PCRVaccineIncidence |
| spellingShingle | Rosângela S.L.A. Torres Talita Z. Santos Robson A.A. Torres Valéria V.G. Pereira Lucas A.F. Fávero Otavio R.M. Filho Margareth L. Penkal Leni S. Araujo Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects Jornal de Pediatria (Versão em Português) Whooping cough Clones Bordetella pertussis Rep‐PCR Vaccine Incidence |
| title | Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects |
| title_full | Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects |
| title_fullStr | Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects |
| title_full_unstemmed | Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects |
| title_short | Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects |
| title_sort | resurgence of pertussis at the age of vaccination clinical epidemiological and molecular aspects |
| topic | Whooping cough Clones Bordetella pertussis Rep‐PCR Vaccine Incidence |
| url | http://www.sciencedirect.com/science/article/pii/S2255553615000580 |
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