Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex
Abstract Background Chronic inflammatory joint diseases (CIJD) have been linked to increased cardiovascular morbidity and mortality. A decisive reason could be a dysregulation of the autonomic nervous system, which is responsible for the control of cardiovascular function. So far, the cause of chang...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-022-05009-1 |
| _version_ | 1798024938477584384 |
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| author | Leona Katharin Danilin Melanie Spindler Peter Sörös Carsten Bantel |
| author_facet | Leona Katharin Danilin Melanie Spindler Peter Sörös Carsten Bantel |
| author_sort | Leona Katharin Danilin |
| collection | DOAJ |
| description | Abstract Background Chronic inflammatory joint diseases (CIJD) have been linked to increased cardiovascular morbidity and mortality. A decisive reason could be a dysregulation of the autonomic nervous system, which is responsible for the control of cardiovascular function. So far, the cause of changes in autonomic nervous system functions remains elusive. In this study, we investigate the role of chronic pain and the insular cortex in autonomic control of cardiac functioning in patients with CIJD. Methods We studied the autonomic nervous system through the assessment of heart rate and heart rate variability (HRV) at rest and under cognitive stimulation. Furthermore, we investigated insular cortex volume by performing surface-based brain morphometry with FreeSurfer. For this study, 47 participants were recruited, 22 individual age- and sex-matched pairs for the magnetic resonance imaging analyses and 14 for the HRV analyses. All available patients’ data were used for analysis. Results Pain duration was negatively correlated with the resting heart rate in patients with chronic inflammatory joint diseases (n = 20). In a multiple linear regression model including only CIJD patients with heart rate at rest as a dependent variable, we found a significant positive relationship between heart rate at rest and the volume of the left insular cortex and a significant negative relationship between heart rate at rest and the volume of the right insular cortex. However, we found no significant differences in HRV parameters or insular cortex volumes between both groups. Conclusions In this study we provide evidence to suggest insular cortex involvement in the process of ANS changes due to chronic pain in CIJD patients. The study was preregistered with the German Clinical Trials Register ( https://www.drks.de ; DRKS00012791; date of registration: 28 July 2017). |
| first_indexed | 2024-04-11T18:10:53Z |
| format | Article |
| id | doaj.art-757f3e669aab4f5d852edc1502a14d9b |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-11T18:10:53Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-757f3e669aab4f5d852edc1502a14d9b2022-12-22T04:10:07ZengBMCBMC Musculoskeletal Disorders1471-24742022-01-0123111210.1186/s12891-022-05009-1Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortexLeona Katharin Danilin0Melanie Spindler1Peter Sörös2Carsten Bantel3Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Evangelisches Krankenhaus OldenburgBiological Psychology, Department of Psychology, School of Medicine and Health Sciences, University of OldenburgNeurology, School of Medicine and Health Sciences, University of OldenburgAnesthesiology, Critical Care, Emergency Medicine, and Pain Management, School of Medicine and Health Sciences, University of OldenburgAbstract Background Chronic inflammatory joint diseases (CIJD) have been linked to increased cardiovascular morbidity and mortality. A decisive reason could be a dysregulation of the autonomic nervous system, which is responsible for the control of cardiovascular function. So far, the cause of changes in autonomic nervous system functions remains elusive. In this study, we investigate the role of chronic pain and the insular cortex in autonomic control of cardiac functioning in patients with CIJD. Methods We studied the autonomic nervous system through the assessment of heart rate and heart rate variability (HRV) at rest and under cognitive stimulation. Furthermore, we investigated insular cortex volume by performing surface-based brain morphometry with FreeSurfer. For this study, 47 participants were recruited, 22 individual age- and sex-matched pairs for the magnetic resonance imaging analyses and 14 for the HRV analyses. All available patients’ data were used for analysis. Results Pain duration was negatively correlated with the resting heart rate in patients with chronic inflammatory joint diseases (n = 20). In a multiple linear regression model including only CIJD patients with heart rate at rest as a dependent variable, we found a significant positive relationship between heart rate at rest and the volume of the left insular cortex and a significant negative relationship between heart rate at rest and the volume of the right insular cortex. However, we found no significant differences in HRV parameters or insular cortex volumes between both groups. Conclusions In this study we provide evidence to suggest insular cortex involvement in the process of ANS changes due to chronic pain in CIJD patients. The study was preregistered with the German Clinical Trials Register ( https://www.drks.de ; DRKS00012791; date of registration: 28 July 2017).https://doi.org/10.1186/s12891-022-05009-1Chronic inflammatory joint diseasesChronic painPain durationInsular cortexHeart rateHeart rate variability |
| spellingShingle | Leona Katharin Danilin Melanie Spindler Peter Sörös Carsten Bantel Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex BMC Musculoskeletal Disorders Chronic inflammatory joint diseases Chronic pain Pain duration Insular cortex Heart rate Heart rate variability |
| title | Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex |
| title_full | Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex |
| title_fullStr | Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex |
| title_full_unstemmed | Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex |
| title_short | Heart rate and heart rate variability in patients with chronic inflammatory joint disease: the role of pain duration and the insular cortex |
| title_sort | heart rate and heart rate variability in patients with chronic inflammatory joint disease the role of pain duration and the insular cortex |
| topic | Chronic inflammatory joint diseases Chronic pain Pain duration Insular cortex Heart rate Heart rate variability |
| url | https://doi.org/10.1186/s12891-022-05009-1 |
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