T-Cell Response to Viral Hemorrhagic Fevers
Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families <i>Arenaviridae</i>, <i>Filoviridae</i>, <i>Hantaviridae</i>, and <i>Flaviviridae</i>. Clinically, this gr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/7/1/11 |
| _version_ | 1798024606413488128 |
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| author | Federico Perdomo-Celis Maria S. Salvato Sandra Medina-Moreno Juan C. Zapata |
| author_facet | Federico Perdomo-Celis Maria S. Salvato Sandra Medina-Moreno Juan C. Zapata |
| author_sort | Federico Perdomo-Celis |
| collection | DOAJ |
| description | Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families <i>Arenaviridae</i>, <i>Filoviridae</i>, <i>Hantaviridae</i>, and <i>Flaviviridae</i>. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents. |
| first_indexed | 2024-04-11T18:05:18Z |
| format | Article |
| id | doaj.art-7580e629ae5a4d49aff17aaf7b0dc108 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-11T18:05:18Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-7580e629ae5a4d49aff17aaf7b0dc1082022-12-22T04:10:20ZengMDPI AGVaccines2076-393X2019-01-01711110.3390/vaccines7010011vaccines7010011T-Cell Response to Viral Hemorrhagic FeversFederico Perdomo-Celis0Maria S. Salvato1Sandra Medina-Moreno2Juan C. Zapata3Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, 050010, ColombiaInstitute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201, USAInstitute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201, USAInstitute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD 21201, USAViral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families <i>Arenaviridae</i>, <i>Filoviridae</i>, <i>Hantaviridae</i>, and <i>Flaviviridae</i>. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.https://www.mdpi.com/2076-393X/7/1/11viral hemorrhagic feverLassa virusEbola virushantavirusyellow fever virusdengue virusT-cellsvaccineinterferon-gammatumor necrosis factor-alpha |
| spellingShingle | Federico Perdomo-Celis Maria S. Salvato Sandra Medina-Moreno Juan C. Zapata T-Cell Response to Viral Hemorrhagic Fevers Vaccines viral hemorrhagic fever Lassa virus Ebola virus hantavirus yellow fever virus dengue virus T-cells vaccine interferon-gamma tumor necrosis factor-alpha |
| title | T-Cell Response to Viral Hemorrhagic Fevers |
| title_full | T-Cell Response to Viral Hemorrhagic Fevers |
| title_fullStr | T-Cell Response to Viral Hemorrhagic Fevers |
| title_full_unstemmed | T-Cell Response to Viral Hemorrhagic Fevers |
| title_short | T-Cell Response to Viral Hemorrhagic Fevers |
| title_sort | t cell response to viral hemorrhagic fevers |
| topic | viral hemorrhagic fever Lassa virus Ebola virus hantavirus yellow fever virus dengue virus T-cells vaccine interferon-gamma tumor necrosis factor-alpha |
| url | https://www.mdpi.com/2076-393X/7/1/11 |
| work_keys_str_mv | AT federicoperdomocelis tcellresponsetoviralhemorrhagicfevers AT mariassalvato tcellresponsetoviralhemorrhagicfevers AT sandramedinamoreno tcellresponsetoviralhemorrhagicfevers AT juanczapata tcellresponsetoviralhemorrhagicfevers |