Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat
Background: Squamous cell carcinoma (SCC) is the most frequent oral cancer. Protec-tive effects of the consumption of vegetables and fruits on various forms of cancer in-cluding oral cancer have been determined. Tomato (Solanum lycopersicum L.) because of its lycopene and bioflavonoids contents poss...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2014-08-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5233&slc_lang=en&sid=1 |
| _version_ | 1811295832768512000 |
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| author | Mohammad Mashayekhi Daryoush Mohajeri Mohammad Reza Valilu |
| author_facet | Mohammad Mashayekhi Daryoush Mohajeri Mohammad Reza Valilu |
| author_sort | Mohammad Mashayekhi |
| collection | DOAJ |
| description | Background: Squamous cell carcinoma (SCC) is the most frequent oral cancer. Protec-tive effects of the consumption of vegetables and fruits on various forms of cancer in-cluding oral cancer have been determined. Tomato (Solanum lycopersicum L.) because of its lycopene and bioflavonoids contents possesses anti-carcinogenic properties. The aim of this study was to evaluate the preventive effects of tomato pulp on pre-neoplastic changes induced by 4-Nitroquinoline-1-oxid (4-NQO) in epithelial cells of lingual mucosa in the rats.
Methods: Forty-eight male Wistar rats were randomly allocated into four equal groups. Group 1 served as control. Groups 2 to 4 assigned to receive 30 ppm 4-NQO in drinking water for 12 consecutive weeks. When the feeding of 4-NQO was started to the rats of groups 3 and 4, they received tomato pulp (20 and 40 ml/kg bw) daily through the oral gavage. Finally, histological evaluations for carcinogenesis were performed for tongues epithelial tissue.
Results: There were no pathological alterations in epithelial tissue of lingual mucosa in control rats. In the epithelial cells of lingual mucosa of 4-NQO treated rats, premalig-nant alterations appeared after 12 weeks of the last application of the drug. Administration of tomato pulp at both doses (20 and 40 ml/kg bw) during the experiment reduced the severity of the lesions, as well as caused a significant reduction in the frequency of pre-neoplastic lesions of tongue epithelial cells (P= 0.024 and P= 0.008). The incidence of severe epithelial cells dysplasia of lingual mucosa in the high dose treatment group was significantly smaller than of low dose treatment group (P= 0.037).
Conclusion: The results obtained showed that tomato pulp is effective in inhibiting the development of neoplasms in epithelial cells of lingual mucosa induced by 4-NQO in the rat. |
| first_indexed | 2024-04-13T05:39:25Z |
| format | Article |
| id | doaj.art-758320d748e9466594f0f49d06272ed5 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-04-13T05:39:25Z |
| publishDate | 2014-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-758320d748e9466594f0f49d06272ed52022-12-22T03:00:10ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222014-08-01725314322Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the ratMohammad Mashayekhi 0Daryoush Mohajeri 1Mohammad Reza Valilu2 Department of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad Uni-versity, Tabriz, Iran. Department of Pathobiology, College of Veterinary Medicine, Tabriz Branch, Islamic Azad Uni-versity, Tabriz, Iran. Department of Pathobiology, College of Veterinary Medicine, Tabriz Branch, Islamic Azad Uni-versity, Tabriz, Iran. Background: Squamous cell carcinoma (SCC) is the most frequent oral cancer. Protec-tive effects of the consumption of vegetables and fruits on various forms of cancer in-cluding oral cancer have been determined. Tomato (Solanum lycopersicum L.) because of its lycopene and bioflavonoids contents possesses anti-carcinogenic properties. The aim of this study was to evaluate the preventive effects of tomato pulp on pre-neoplastic changes induced by 4-Nitroquinoline-1-oxid (4-NQO) in epithelial cells of lingual mucosa in the rats. Methods: Forty-eight male Wistar rats were randomly allocated into four equal groups. Group 1 served as control. Groups 2 to 4 assigned to receive 30 ppm 4-NQO in drinking water for 12 consecutive weeks. When the feeding of 4-NQO was started to the rats of groups 3 and 4, they received tomato pulp (20 and 40 ml/kg bw) daily through the oral gavage. Finally, histological evaluations for carcinogenesis were performed for tongues epithelial tissue. Results: There were no pathological alterations in epithelial tissue of lingual mucosa in control rats. In the epithelial cells of lingual mucosa of 4-NQO treated rats, premalig-nant alterations appeared after 12 weeks of the last application of the drug. Administration of tomato pulp at both doses (20 and 40 ml/kg bw) during the experiment reduced the severity of the lesions, as well as caused a significant reduction in the frequency of pre-neoplastic lesions of tongue epithelial cells (P= 0.024 and P= 0.008). The incidence of severe epithelial cells dysplasia of lingual mucosa in the high dose treatment group was significantly smaller than of low dose treatment group (P= 0.037). Conclusion: The results obtained showed that tomato pulp is effective in inhibiting the development of neoplasms in epithelial cells of lingual mucosa induced by 4-NQO in the rat.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5233&slc_lang=en&sid=14-Nitroquinoline-1-oxid carcinogenesis Lycopersicon esculentum mouth rats. |
| spellingShingle | Mohammad Mashayekhi Daryoush Mohajeri Mohammad Reza Valilu Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat Tehran University Medical Journal 4-Nitroquinoline-1-oxid carcinogenesis Lycopersicon esculentum mouth rats. |
| title | Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat |
| title_full | Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat |
| title_fullStr | Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat |
| title_full_unstemmed | Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat |
| title_short | Preventive effects of tomato pulp on oral pre-neoplastic changes in-duced by 4-Nitroquinoline-1-oxid in the rat |
| title_sort | preventive effects of tomato pulp on oral pre neoplastic changes in duced by 4 nitroquinoline 1 oxid in the rat |
| topic | 4-Nitroquinoline-1-oxid carcinogenesis Lycopersicon esculentum mouth rats. |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5233&slc_lang=en&sid=1 |
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