The Role of the Microbiome in First Episode of Psychosis
The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, includ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1770 |
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| author | Lucero Nuncio-Mora Nuria Lanzagorta Humberto Nicolini Emmanuel Sarmiento Galo Ortiz Fernanda Sosa Alma Delia Genis-Mendoza |
| author_facet | Lucero Nuncio-Mora Nuria Lanzagorta Humberto Nicolini Emmanuel Sarmiento Galo Ortiz Fernanda Sosa Alma Delia Genis-Mendoza |
| author_sort | Lucero Nuncio-Mora |
| collection | DOAJ |
| description | The relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, including psychosis. The aim of this review is to summarize the clinical and preclinical studies that have evaluated the differences in microbiota as well as the metabolic consequences related to psychosis. Current data suggest that the genera <i>Lactobacillus</i> and <i>Megasphaera</i> are increased in schizophrenia (SZ), as well as alterations in the glutamate-glutamine-GABA cycle, serum levels of tryptophan, kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). There are still very few studies on early-onset psychosis, thus more studies are needed to be able to propose targeted therapies for a point when the disease has just started or has not yet progressed. |
| first_indexed | 2024-03-11T02:43:46Z |
| format | Article |
| id | doaj.art-75834915e6fd44878c0466763c20ebce |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:43:46Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-75834915e6fd44878c0466763c20ebce2023-11-18T09:27:56ZengMDPI AGBiomedicines2227-90592023-06-01116177010.3390/biomedicines11061770The Role of the Microbiome in First Episode of PsychosisLucero Nuncio-Mora0Nuria Lanzagorta1Humberto Nicolini2Emmanuel Sarmiento3Galo Ortiz4Fernanda Sosa5Alma Delia Genis-Mendoza6Laboratory of Genomics of Psychiatric and Neurodegenerative Diseases, National Institute of Genomic Medicine, Mexico City 14610, MexicoCarraci Medical Group, Mexico City 03740, MexicoLaboratory of Genomics of Psychiatric and Neurodegenerative Diseases, National Institute of Genomic Medicine, Mexico City 14610, MexicoPsychiatric Children’s Hospital Dr. Juan N. Navarro, Mexico City 14080, MexicoPsychiatric Children’s Hospital Dr. Juan N. Navarro, Mexico City 14080, MexicoCarraci Medical Group, Mexico City 03740, MexicoLaboratory of Genomics of Psychiatric and Neurodegenerative Diseases, National Institute of Genomic Medicine, Mexico City 14610, MexicoThe relationship between the gut-brain-microbiome axis has gained great importance in the study of psychiatric disorders, as it may represent a new target for their treatment. To date, the available literature suggests that the microbiota may influence the pathophysiology of several diseases, including psychosis. The aim of this review is to summarize the clinical and preclinical studies that have evaluated the differences in microbiota as well as the metabolic consequences related to psychosis. Current data suggest that the genera <i>Lactobacillus</i> and <i>Megasphaera</i> are increased in schizophrenia (SZ), as well as alterations in the glutamate-glutamine-GABA cycle, serum levels of tryptophan, kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). There are still very few studies on early-onset psychosis, thus more studies are needed to be able to propose targeted therapies for a point when the disease has just started or has not yet progressed.https://www.mdpi.com/2227-9059/11/6/1770microbiomedysbiosisfirst episode of psychosisbrain-gut-microbiome axis |
| spellingShingle | Lucero Nuncio-Mora Nuria Lanzagorta Humberto Nicolini Emmanuel Sarmiento Galo Ortiz Fernanda Sosa Alma Delia Genis-Mendoza The Role of the Microbiome in First Episode of Psychosis Biomedicines microbiome dysbiosis first episode of psychosis brain-gut-microbiome axis |
| title | The Role of the Microbiome in First Episode of Psychosis |
| title_full | The Role of the Microbiome in First Episode of Psychosis |
| title_fullStr | The Role of the Microbiome in First Episode of Psychosis |
| title_full_unstemmed | The Role of the Microbiome in First Episode of Psychosis |
| title_short | The Role of the Microbiome in First Episode of Psychosis |
| title_sort | role of the microbiome in first episode of psychosis |
| topic | microbiome dysbiosis first episode of psychosis brain-gut-microbiome axis |
| url | https://www.mdpi.com/2227-9059/11/6/1770 |
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