Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery
The concept of targeted drug delivery can be described in terms of the drug systems’ ability to mimic the biological objects’ property to localize to target cells or tissues. For example, drug delivery systems based on red blood cells or mimicking some of their useful features, such as long circulat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Biomimetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-7673/8/7/543 |
| _version_ | 1797459981095665664 |
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| author | Ivan V. Savchenko Igor D. Zlotnikov Elena V. Kudryashova |
| author_facet | Ivan V. Savchenko Igor D. Zlotnikov Elena V. Kudryashova |
| author_sort | Ivan V. Savchenko |
| collection | DOAJ |
| description | The concept of targeted drug delivery can be described in terms of the drug systems’ ability to mimic the biological objects’ property to localize to target cells or tissues. For example, drug delivery systems based on red blood cells or mimicking some of their useful features, such as long circulation in stealth mode, have been known for decades. On the contrary, therapeutic strategies based on macrophages have gained very limited attention until recently. Here, we review two biomimetic strategies associated with macrophages that can be used to develop new therapeutic modalities: first, the mimicry of certain types of macrophages (i.e., the use of macrophages, including tumor-associated or macrophage-derived particles as a carrier for the targeted delivery of therapeutic agents); second, the mimicry of ligands, naturally absorbed by macrophages (i.e., the use of therapeutic agents specifically targeted at macrophages). We discuss the potential applications of biomimetic systems involving macrophages for new advancements in the treatment of infections, inflammatory diseases, and cancer. |
| first_indexed | 2024-03-09T16:59:29Z |
| format | Article |
| id | doaj.art-7584ba891134440ab4a57b9ac2d924bb |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-09T16:59:29Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-7584ba891134440ab4a57b9ac2d924bb2023-11-24T14:31:41ZengMDPI AGBiomimetics2313-76732023-11-018754310.3390/biomimetics8070543Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug DeliveryIvan V. Savchenko0Igor D. Zlotnikov1Elena V. Kudryashova2Faculty of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, RussiaThe concept of targeted drug delivery can be described in terms of the drug systems’ ability to mimic the biological objects’ property to localize to target cells or tissues. For example, drug delivery systems based on red blood cells or mimicking some of their useful features, such as long circulation in stealth mode, have been known for decades. On the contrary, therapeutic strategies based on macrophages have gained very limited attention until recently. Here, we review two biomimetic strategies associated with macrophages that can be used to develop new therapeutic modalities: first, the mimicry of certain types of macrophages (i.e., the use of macrophages, including tumor-associated or macrophage-derived particles as a carrier for the targeted delivery of therapeutic agents); second, the mimicry of ligands, naturally absorbed by macrophages (i.e., the use of therapeutic agents specifically targeted at macrophages). We discuss the potential applications of biomimetic systems involving macrophages for new advancements in the treatment of infections, inflammatory diseases, and cancer.https://www.mdpi.com/2313-7673/8/7/543macrophage-mediated therapymacrophage biomimeticsmacrophage-derived particlesselective ligands |
| spellingShingle | Ivan V. Savchenko Igor D. Zlotnikov Elena V. Kudryashova Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery Biomimetics macrophage-mediated therapy macrophage biomimetics macrophage-derived particles selective ligands |
| title | Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery |
| title_full | Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery |
| title_fullStr | Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery |
| title_full_unstemmed | Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery |
| title_short | Biomimetic Systems Involving Macrophages and Their Potential for Targeted Drug Delivery |
| title_sort | biomimetic systems involving macrophages and their potential for targeted drug delivery |
| topic | macrophage-mediated therapy macrophage biomimetics macrophage-derived particles selective ligands |
| url | https://www.mdpi.com/2313-7673/8/7/543 |
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