Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.)
Dendrobium nobile (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (1–19), including two new vitamin E homologues (1–2), one new sesquiterpene (6), and two new dendrobines (7, 8), were isolated an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.988459/full |
| _version_ | 1811229713416323072 |
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| author | Hui Lei Shunmei Zou Jiafu Lin Longfei Zhai Yifeng Zhang Xiujuan Fu Siwei Chen Hong Niu Feifei Liu Chunlian Wu Dan Zhang |
| author_facet | Hui Lei Shunmei Zou Jiafu Lin Longfei Zhai Yifeng Zhang Xiujuan Fu Siwei Chen Hong Niu Feifei Liu Chunlian Wu Dan Zhang |
| author_sort | Hui Lei |
| collection | DOAJ |
| description | Dendrobium nobile (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (1–19), including two new vitamin E homologues (1–2), one new sesquiterpene (6), and two new dendrobines (7, 8), were isolated and identified from stems of Dendrobium nobile. Their structures were elucidated on the basis of NMR, 13C NMR calculation, and DP4+ probability analyses. The absolute configurations of new compounds were determined by electronic circular dichroism (ECD) data analysis. Antioxidant, anti-inflammatory, and cytotoxic activities of isolated compounds were evaluated. Among them, compound 2 demonstrated significant antioxidant activity compared with ascorbic acid (VC), while compounds 2 and 4 also exhibited an equal effect to positive control cisplatin. This study on the biological activity of the new vitamin E homologues from Dendrobium nobile may indicate its potential application in the pharmaceutical and food industries. |
| first_indexed | 2024-04-12T10:19:09Z |
| format | Article |
| id | doaj.art-75850b96421e429d9bf223c7bf9ce2de |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-12T10:19:09Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-75850b96421e429d9bf223c7bf9ce2de2022-12-22T03:37:08ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-10-011010.3389/fchem.2022.988459988459Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.)Hui Lei0Shunmei Zou1Jiafu Lin2Longfei Zhai3Yifeng Zhang4Xiujuan Fu5Siwei Chen6Hong Niu7Feifei Liu8Chunlian Wu9Dan Zhang10School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Pharmacy, Chengdu University, Chengdu, Sichuan, ChinaAntibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, Sichuan, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaSchool of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu, ChinaKey Laboratory of Southwest China Wildlife Resources Conservation (China West Normal University), Ministry of Education, Nanchong, Sichuan, ChinaSchool of Pharmacy, Southwest Medical University, Luzhou, Sichuan, ChinaDendrobium nobile (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (1–19), including two new vitamin E homologues (1–2), one new sesquiterpene (6), and two new dendrobines (7, 8), were isolated and identified from stems of Dendrobium nobile. Their structures were elucidated on the basis of NMR, 13C NMR calculation, and DP4+ probability analyses. The absolute configurations of new compounds were determined by electronic circular dichroism (ECD) data analysis. Antioxidant, anti-inflammatory, and cytotoxic activities of isolated compounds were evaluated. Among them, compound 2 demonstrated significant antioxidant activity compared with ascorbic acid (VC), while compounds 2 and 4 also exhibited an equal effect to positive control cisplatin. This study on the biological activity of the new vitamin E homologues from Dendrobium nobile may indicate its potential application in the pharmaceutical and food industries.https://www.frontiersin.org/articles/10.3389/fchem.2022.988459/fullDendrobium nobile Lindl.chemical constituentsantioxidantanti-inflammatory activitiesstructure-activity relationship |
| spellingShingle | Hui Lei Shunmei Zou Jiafu Lin Longfei Zhai Yifeng Zhang Xiujuan Fu Siwei Chen Hong Niu Feifei Liu Chunlian Wu Dan Zhang Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.) Frontiers in Chemistry Dendrobium nobile Lindl. chemical constituents antioxidant anti-inflammatory activities structure-activity relationship |
| title | Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.) |
| title_full | Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.) |
| title_fullStr | Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.) |
| title_full_unstemmed | Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.) |
| title_short | Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.) |
| title_sort | antioxidant and anti inflammatory activity of constituents isolated from dendrobium nobile lindl |
| topic | Dendrobium nobile Lindl. chemical constituents antioxidant anti-inflammatory activities structure-activity relationship |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.988459/full |
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