Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis

Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis

Summary: Although maternal exercise (ME) becomes increasingly uncommon, the effects of ME on offspring muscle metabolic health remain largely undefined. Maternal mice are subject to daily exercise during pregnancy, which enhances mitochondrial biogenesis during fetal muscle development; this is corr...

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Bibliographic Details
Main Authors: Jun Seok Son, Song Ah Chae, Hongyang Wang, Yanting Chen, Alejandro Bravo Iniguez, Jeanene M. de Avila, Zhihua Jiang, Mei-Jun Zhu, Min Du
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
fetus
PGC-1α
DNA methylation
endurance capacity
mitochondrial biogenesis
maternal exercise
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314509

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