Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay
Abstract Objective Recently, the stress hyperglycemia ratio (SHR) has been introduced as a metric to signify relative hyperglycemia. This study aimed to investigate the relationship between SHR and in-hospital mortality and length of stay occurring during hospitalization in stroke patients. Methods...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-024-01303-1 |
| _version_ | 1797259154035834880 |
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| author | Di Shen Xintian Cai Qing Zhu Mulalibieke Heizhati Junli Hu Shuaiwei Song Wenbo Yang Jing Hong Nanfang Li |
| author_facet | Di Shen Xintian Cai Qing Zhu Mulalibieke Heizhati Junli Hu Shuaiwei Song Wenbo Yang Jing Hong Nanfang Li |
| author_sort | Di Shen |
| collection | DOAJ |
| description | Abstract Objective Recently, the stress hyperglycemia ratio (SHR) has been introduced as a metric to signify relative hyperglycemia. This study aimed to investigate the relationship between SHR and in-hospital mortality and length of stay occurring during hospitalization in stroke patients. Methods The retrospective cohort study comprised a total of 4,018 patients diagnosed with acute stroke. The SHR is expressed by the formula: SHR = ABG (mmol/L) / [1.59 × HbA1c (%) − 2.59]. Outcomes included in-hospital mortality and length of stay. Multivariable logistic and linear regression analyses were conducted. Receiver operating characteristic (ROC) analysis was performed to distinguish between the variables, and the area under the ROC curve (AUC) was compared. Results In this analysis, a total of 4,018 individuals participated, including 2,814 male patients, accounting for 70.0%. Overall, in-hospital mortality and length of stay tended to rise as SHR increased. A higher prevalence of in-hospital mortality was observed with each standard deviation (SD) increase of the SHR (odds ratio [OR]: 1.26, 95% confidence interval [CI]: 1.05–1.52). Moreover, after considering the confounders, a significant positive association between SHR levels and length of stay was observed (β = 0.70, 95% CI: 0.40-1.00). ROC analysis showed that among stroke patients, SHR (AUC = 0.693) was more effective than admission blood glucose (ABG) (AUC = 0.646) and glycosylated hemoglobin (HbA1c) (AUC = 0.523), which were more predictive of in-hospital mortality. Conclusions Elevated SHR levels are associated with increased in-hospital mortality and prolonged length of stay in stroke patients. |
| first_indexed | 2024-04-24T23:04:55Z |
| format | Article |
| id | doaj.art-7586394003494720a96c64bf6b17f6c9 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-24T23:04:55Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
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| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-7586394003494720a96c64bf6b17f6c92024-03-17T12:33:36ZengBMCDiabetology & Metabolic Syndrome1758-59962024-03-011611910.1186/s13098-024-01303-1Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stayDi Shen0Xintian Cai1Qing Zhu2Mulalibieke Heizhati3Junli Hu4Shuaiwei Song5Wenbo Yang6Jing Hong7Nanfang Li8Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension InstituteAbstract Objective Recently, the stress hyperglycemia ratio (SHR) has been introduced as a metric to signify relative hyperglycemia. This study aimed to investigate the relationship between SHR and in-hospital mortality and length of stay occurring during hospitalization in stroke patients. Methods The retrospective cohort study comprised a total of 4,018 patients diagnosed with acute stroke. The SHR is expressed by the formula: SHR = ABG (mmol/L) / [1.59 × HbA1c (%) − 2.59]. Outcomes included in-hospital mortality and length of stay. Multivariable logistic and linear regression analyses were conducted. Receiver operating characteristic (ROC) analysis was performed to distinguish between the variables, and the area under the ROC curve (AUC) was compared. Results In this analysis, a total of 4,018 individuals participated, including 2,814 male patients, accounting for 70.0%. Overall, in-hospital mortality and length of stay tended to rise as SHR increased. A higher prevalence of in-hospital mortality was observed with each standard deviation (SD) increase of the SHR (odds ratio [OR]: 1.26, 95% confidence interval [CI]: 1.05–1.52). Moreover, after considering the confounders, a significant positive association between SHR levels and length of stay was observed (β = 0.70, 95% CI: 0.40-1.00). ROC analysis showed that among stroke patients, SHR (AUC = 0.693) was more effective than admission blood glucose (ABG) (AUC = 0.646) and glycosylated hemoglobin (HbA1c) (AUC = 0.523), which were more predictive of in-hospital mortality. Conclusions Elevated SHR levels are associated with increased in-hospital mortality and prolonged length of stay in stroke patients.https://doi.org/10.1186/s13098-024-01303-1StrokeStress hyperglycemia ratioIn-hospital mortalityLength of stay |
| spellingShingle | Di Shen Xintian Cai Qing Zhu Mulalibieke Heizhati Junli Hu Shuaiwei Song Wenbo Yang Jing Hong Nanfang Li Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay Diabetology & Metabolic Syndrome Stroke Stress hyperglycemia ratio In-hospital mortality Length of stay |
| title | Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay |
| title_full | Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay |
| title_fullStr | Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay |
| title_full_unstemmed | Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay |
| title_short | Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay |
| title_sort | increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in hospital mortality and length of stay |
| topic | Stroke Stress hyperglycemia ratio In-hospital mortality Length of stay |
| url | https://doi.org/10.1186/s13098-024-01303-1 |
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