Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine
The antioxidant properties of melatonin can be successfully used to reduce the effects of oxidative stress caused by homocysteine. The beneficial actions of melatonin are mainly due to its ability to inhibit the generation of the hydroxyl radical during the oxidation of homocysteine. Melatonin prote...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/8/1178 |
| _version_ | 1797524846140194816 |
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| author | Kamil Karolczak Cezary Watala |
| author_facet | Kamil Karolczak Cezary Watala |
| author_sort | Kamil Karolczak |
| collection | DOAJ |
| description | The antioxidant properties of melatonin can be successfully used to reduce the effects of oxidative stress caused by homocysteine. The beneficial actions of melatonin are mainly due to its ability to inhibit the generation of the hydroxyl radical during the oxidation of homocysteine. Melatonin protects endothelial cells, neurons, and glia against the action of oxygen radicals generated by homocysteine and prevents the structural changes in cells that lead to impaired contractility of blood vessels and neuronal degeneration. It can be, therefore, assumed that the results obtained in experiments performed mainly in the in vitro models and occasionally in animal models may clear the way to clinical applications of melatonin in patients with hyperhomocysteinemia, who exhibit a higher risk of developing neurodegenerative diseases (e.g., Parkinson’s disease or Alzheimer’s disease) and cardiovascular diseases of atherothrombotic etiology. However, the results that have been obtained so far are scarce and have seldom been performed on advanced in vivo models. All findings predominately originate from the use of in vitro models and the scarcity of clinical evidence is huge. Thus, this mini-review should be considered as a summary of the outcomes of the initial research in the field concerning the use of melatonin as a possibly efficient attenuator of oxidative stress induced by homocysteine. |
| first_indexed | 2024-03-10T09:03:22Z |
| format | Article |
| id | doaj.art-758b10fb29ab47efbd003e3c0488078e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T09:03:22Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-758b10fb29ab47efbd003e3c0488078e2023-11-22T06:35:14ZengMDPI AGAntioxidants2076-39212021-07-01108117810.3390/antiox10081178Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by HomocysteineKamil Karolczak0Cezary Watala1Department of Haemostatic Disorders, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, PolandDepartment of Haemostatic Disorders, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, PolandThe antioxidant properties of melatonin can be successfully used to reduce the effects of oxidative stress caused by homocysteine. The beneficial actions of melatonin are mainly due to its ability to inhibit the generation of the hydroxyl radical during the oxidation of homocysteine. Melatonin protects endothelial cells, neurons, and glia against the action of oxygen radicals generated by homocysteine and prevents the structural changes in cells that lead to impaired contractility of blood vessels and neuronal degeneration. It can be, therefore, assumed that the results obtained in experiments performed mainly in the in vitro models and occasionally in animal models may clear the way to clinical applications of melatonin in patients with hyperhomocysteinemia, who exhibit a higher risk of developing neurodegenerative diseases (e.g., Parkinson’s disease or Alzheimer’s disease) and cardiovascular diseases of atherothrombotic etiology. However, the results that have been obtained so far are scarce and have seldom been performed on advanced in vivo models. All findings predominately originate from the use of in vitro models and the scarcity of clinical evidence is huge. Thus, this mini-review should be considered as a summary of the outcomes of the initial research in the field concerning the use of melatonin as a possibly efficient attenuator of oxidative stress induced by homocysteine.https://www.mdpi.com/2076-3921/10/8/1178melatoninhomocysteineoxidative stressneurotoxicitycardiovascular diseases |
| spellingShingle | Kamil Karolczak Cezary Watala Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine Antioxidants melatonin homocysteine oxidative stress neurotoxicity cardiovascular diseases |
| title | Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine |
| title_full | Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine |
| title_fullStr | Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine |
| title_full_unstemmed | Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine |
| title_short | Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine |
| title_sort | melatonin as a reducer of neuro and vasculotoxic oxidative stress induced by homocysteine |
| topic | melatonin homocysteine oxidative stress neurotoxicity cardiovascular diseases |
| url | https://www.mdpi.com/2076-3921/10/8/1178 |
| work_keys_str_mv | AT kamilkarolczak melatoninasareducerofneuroandvasculotoxicoxidativestressinducedbyhomocysteine AT cezarywatala melatoninasareducerofneuroandvasculotoxicoxidativestressinducedbyhomocysteine |