The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner

The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner

The NRF2/KEAP1 pathway protects healthy cells from malignant transformation and maintains cellular homeostasis. Up to 30% of human lung tumors gain constitutive NRF2 activity which contributes to cancer cell survival and chemoresistance, but the effects of NRF2 activation in immune cells within the...

Full description

Bibliographic Details
Main Authors: Jessica A. Moerland, Ana S. Leal, Beth Lockwood, Elena Y. Demireva, Huirong Xie, Teresa Krieger-Burke, Karen T. Liby
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
Nrf2
Keap1
Nrf2 regulators
lung cancer
macrophages
CDDO-Methyl ester
Online Access:https://www.mdpi.com/2076-3921/12/1/116

Similar Items

Similar Items