Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes

Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes

Abstract Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune cells lack mRNA expression of both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type 2 (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplas...

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Bibliographic Details
Main Authors: Yi Yao, Kalpana Subedi, Tingting Liu, Namir Khalasawi, Carla Diana Pretto-Kernahan, Jesse William Wotring, Jie Wang, Congcong Yin, Aimin Jiang, Chunmei Fu, Peter Dimitrion, Jia Li, Jesse Veenstra, Qijun Yi, Kathy McKinnon, John Ernest McKinnon, Jonathan Zachary Sexton, Li Zhou, Qing-Sheng Mi
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00453-8

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