The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies
The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2021.701080/full |
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| author | Yuichi Takeuchi Anett J. Nagy Lívia Barcsai Qun Li Masahiro Ohsawa Kenji Mizuseki Antal Berényi Antal Berényi Antal Berényi Antal Berényi |
| author_facet | Yuichi Takeuchi Anett J. Nagy Lívia Barcsai Qun Li Masahiro Ohsawa Kenji Mizuseki Antal Berényi Antal Berényi Antal Berényi Antal Berényi |
| author_sort | Yuichi Takeuchi |
| collection | DOAJ |
| description | The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer’s disease, anxiety/fear, schizophrenia, and depression, as well as pain. |
| first_indexed | 2024-12-22T06:52:19Z |
| format | Article |
| id | doaj.art-758f79fdd92a4c2f840146f220e087c7 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-22T06:52:19Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-758f79fdd92a4c2f840146f220e087c72022-12-21T18:35:06ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102021-07-011510.3389/fncir.2021.701080701080The Medial Septum as a Potential Target for Treating Brain Disorders Associated With OscillopathiesYuichi Takeuchi0Anett J. Nagy1Lívia Barcsai2Qun Li3Masahiro Ohsawa4Kenji Mizuseki5Antal Berényi6Antal Berényi7Antal Berényi8Antal Berényi9Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, JapanMTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryMTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryMTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryDepartment of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, JapanDepartment of Physiology, Osaka City University Graduate School of Medicine, Osaka, JapanMTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, HungaryNeurocybernetics Excellence Center, University of Szeged, Szeged, HungaryHCEMM-USZ Magnetotherapeutics Research Group, University of Szeged, Szeged, HungaryNeuroscience Institute, New York University, New York, NY, United StatesThe medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer’s disease, anxiety/fear, schizophrenia, and depression, as well as pain.https://www.frontiersin.org/articles/10.3389/fncir.2021.701080/fullmedial septumoscillationoscillopathydeep brain stimulationepilepsyAlzheimer’s disease |
| spellingShingle | Yuichi Takeuchi Anett J. Nagy Lívia Barcsai Qun Li Masahiro Ohsawa Kenji Mizuseki Antal Berényi Antal Berényi Antal Berényi Antal Berényi The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies Frontiers in Neural Circuits medial septum oscillation oscillopathy deep brain stimulation epilepsy Alzheimer’s disease |
| title | The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies |
| title_full | The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies |
| title_fullStr | The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies |
| title_full_unstemmed | The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies |
| title_short | The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies |
| title_sort | medial septum as a potential target for treating brain disorders associated with oscillopathies |
| topic | medial septum oscillation oscillopathy deep brain stimulation epilepsy Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2021.701080/full |
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