Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats
Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced en...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/10/368 |
| _version_ | 1798043434858053632 |
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| author | Jeong Hwan Oh Jae Sue Choi Taek-Jeong Nam |
| author_facet | Jeong Hwan Oh Jae Sue Choi Taek-Jeong Nam |
| author_sort | Jeong Hwan Oh |
| collection | DOAJ |
| description | Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) stress and cognitive impairment. Fucosterol was isolated from the edible brown seaweed Ecklonia stolonifera, and its neuroprotective effects were analyzed in primary hippocampal neurons and in aging rats. Fucosterol attenuated sAβ1-42-induced decrease in the viability of hippocampal neurons and downregulated sAβ1-42-induced increase in glucose-regulated protein 78 (GRP78) expression in hippocampal neurons via activation of tyrosine receptor kinase B-mediated ERK1/2 signaling. Fucosterol co-infusion attenuated sAβ1-42-induced cognitive impairment in aging rats via downregulation of GRP78 expression and upregulation of mature brain-derived neurotrophic factor expression in the dentate gyrus. Fucosterol might be beneficial for the management of cognitive dysfunction via suppression of aging-induced ER stress. |
| first_indexed | 2024-04-11T22:49:02Z |
| format | Article |
| id | doaj.art-758ff1e780a941239393753b8a07f3f9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:49:02Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-758ff1e780a941239393753b8a07f3f92022-12-22T03:58:38ZengMDPI AGMarine Drugs1660-33972018-10-01161036810.3390/md16100368md16100368Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging RatsJeong Hwan Oh0Jae Sue Choi1Taek-Jeong Nam2Institute of Fisheries Sciences, Pukyong National University, Busan 46041, KoreaDepartment of Food Science and Nutrition, Pukyong National University, Busan 48513, KoreaInstitute of Fisheries Sciences, Pukyong National University, Busan 46041, KoreaFucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) stress and cognitive impairment. Fucosterol was isolated from the edible brown seaweed Ecklonia stolonifera, and its neuroprotective effects were analyzed in primary hippocampal neurons and in aging rats. Fucosterol attenuated sAβ1-42-induced decrease in the viability of hippocampal neurons and downregulated sAβ1-42-induced increase in glucose-regulated protein 78 (GRP78) expression in hippocampal neurons via activation of tyrosine receptor kinase B-mediated ERK1/2 signaling. Fucosterol co-infusion attenuated sAβ1-42-induced cognitive impairment in aging rats via downregulation of GRP78 expression and upregulation of mature brain-derived neurotrophic factor expression in the dentate gyrus. Fucosterol might be beneficial for the management of cognitive dysfunction via suppression of aging-induced ER stress.http://www.mdpi.com/1660-3397/16/10/368soluble amyloid peptideendoplasmic reticulum stressfucosterolbrain-derived neurotrophic factorEcklonia stolonifera |
| spellingShingle | Jeong Hwan Oh Jae Sue Choi Taek-Jeong Nam Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats Marine Drugs soluble amyloid peptide endoplasmic reticulum stress fucosterol brain-derived neurotrophic factor Ecklonia stolonifera |
| title | Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats |
| title_full | Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats |
| title_fullStr | Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats |
| title_full_unstemmed | Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats |
| title_short | Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats |
| title_sort | fucosterol from an edible brown alga ecklonia stolonifera prevents soluble amyloid beta induced cognitive dysfunction in aging rats |
| topic | soluble amyloid peptide endoplasmic reticulum stress fucosterol brain-derived neurotrophic factor Ecklonia stolonifera |
| url | http://www.mdpi.com/1660-3397/16/10/368 |
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